Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1 (5-Year IF – 2.0)
Journal Citation Indicator (JCI) (2023) – 0.4
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Index Copernicus  – 171.00; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2020, vol. 29, nr 11, November, p. 1313–1317

doi: 10.17219/acem/126292

Publication type: original article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Neutrophil to lymphocyte ratio as noninvasive predictor of pulmonary vascular resistance increase in congestive heart failure patients: Single-center preliminary report

Tomasz Kamil Urbanowicz1,A,B,C,D,E,F, Anna Olasińska-Wiśniewska2,C,D,E,F, Michał Michalak3,C,E, Ewa Straburzyńska-Migaj4,A,B,D,E,F, Marek Jemielity2,A,E,F

1 Cardiac Surgery and Transplantology Department, University Hospital of Lord’s Transfiguration, Poznan University of Medical Sciences, Poland

2 Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poland

3 Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poland

4 Department of Cardiology, Poznan University of Medical Sciences, Poland

Abstract

Background. Nowadays, heart failure (HF) is a significant health problem due to steady increase in diagnosis, unpredictable acute decompensations and high mortality rate. Early risk stratifications of clinical deterioration are essential in preventing life-threatening events and ensuring proper patients management. Increased neutrophil to lymphocytes ratio (NTLR) above 6 is associated with the risk of re-hospitalizations and increased mortality.
Objectives. To compare NTLR and clinical, laboratory and hemodynamic results obtained from patients re-hospitalized within six-month intervals due to HF decompensation.
Material and Methods. We evaluated 41 patients (n = 36 males (87%) and n = 5 females (13%), mean age 50 ±10 years) admitted to our hospital at least twice within six-month interval due to decompensation of chronic heart failure (CHF) between 2017 and 2019. All patients were divided into 2 groups depending on the NTLR values.
Results. There was no death in presented group during the observational time. We observed a significant difference in cardiac index (CI) – 2.4 ±0.5 compared to 2.6 ±0.6 L/m2/min – between the 1st and 2nd admission (p = 0.0356). The right ventricle systolic pressure (RVSP) results related to NTLR level revealed significant difference (43 ±14 mm Hg compared to 59 ±21 mm Hg, p = 0.0438). We observed a significant increase of pulmonary vascular resistance (PVR) values (175 ±106 compared to 438 ±300 dyn*s*cm−5, p = 0.0386) in patients with NTLR above 6.
Conclusion. Neutrophil to lymphocyte ratio may be an easy and suitable tool for monitoring of the HF progression. According to our study, the ratio correlates with PVR and RVSP increase.

Key words

neutrophils, heart failure, pulmonary hypertension, pulmonary vascular resistance

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