Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2020, vol. 29, nr 1, January, p. 63–70

doi: 10.17219/acem/111808

Publication type: original article

Language: English

License: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Cardiovascular risk factors and the concentration of asymmetric dimethylarginine

Paweł Gać1,2,A,D,F, Małgorzata Poręba3,C,D,E,F, Marta Jurdziak1,B,C,D,F, Ewa Trzmielewska1,B,E,F, Katarzyna Gocławska1,B,E,F, Arkadiusz Derkacz1,E,F, Grzegorz Mazur1,E,F, Andrzej Szuba4,5,A,E,F, Rafał Poręba1,A,C,E,F

1 Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Poland

2 Department of Hygiene, Wroclaw Medical University, Poland

3 Department of Pathophysiology, Wroclaw Medical University, Poland

4 Department of Internal Medicine, 4th Military Hospital, Wrocław, Poland

5 Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Poland


Background. The most commonly recognized cardiovascular risk factors (CVRF) include smoking cigarettes, manifestation of arterial hypertension (AH), hypercholesterolemia, hypertriglyceridemia, manifestation of type 2 diabetes mellitus (DM), and the presence of overweight or obesity. In recent years, investigations have documented the significance of asymmetric dimethylarginine concentration (ADMA) in the pathogenesis of diseases affecting the cardiovascular system.
Objectives. To evaluate the relationship between the number of CVRF and blood ADMA concentration.
Material and Methods. The study was conducted on a sample of 138 individuals (mean age 54.90 ±10.38 years). Among the participants, we distniguished subgroups with no CVRF (group A, n = 21), with 1–2 CVRF (group B, n = 53), with 3–4 CVRF (group C, n = 55), and with 5–6 CVRF (group D, n = 9). Plasma concentrations of arginine and of endogenous methylarginines were estimated.
Results. Plasma ADMA concentrations proved to be significantly higher in groups B, C and D than those in group A. Regression analysis allowed us to demonstrate that in the studied population of patients, manifestation of type 2 DM, followed by AH and hypercholesterolemia, were linked to the highest probability of elevated plasma ADMA concentration.
Conclusion. Higher concentration of ADMA in the blood may be a marker for higher cardiovascular risk, especially associated with hypertension, type 2 DM and hypercholesterolemia.

Key words

type 2 diabetes mellitus, arterial hypertension, cardiovascular risk factors, endogenous methylarginines, asymmetric dimethylarginine

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