Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2019, vol. 28, nr 9, September, p. 1249–1255

doi: 10.17219/acem/68364

Publication type: original article

Language: English

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Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population

Xian-Jin Chen1,A,B,C,D,E,F, Li-Li Chang2,B,C,E,F, Qi Wang1,B,C,E,F, Chun-Yu Han1,C,E,F, Wen-Jun Li3,C,E,F, Fu-Jun Tian4,A,B,C,D,E,F, Li-Qian Liu4,C,E,F

1 Department of Dermatology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, China

2 Department of Intensive Care Unit, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, China

3 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, China

4 Department of Dermatology, Linyi People’s Hospital, China

Abstract

Background. The single-nucleotide polymorphisms (SNPs) of apurinic/apyrimidinicendonuclease 1 (APE1), which has been implicated in cancers and the DNA base excision repair (BER) process, have not been thoroughly investigated in association with the risks of oxidative stress-related vitiligo.
Objectives. The aim of this study is to investigate associations between APE1 single-nucleotide polymorphisms 141T >G and 1349T >G and risk and prognosis of vitiligo.
Material and Methods. From June 2013 to June 2015, a total of 460 vitiligo patients were randomly recruited as a case group; 200 of these patients received narrow bound ultraviolet B (NB-UVB) treatment. Meanwhile, 460 healthy controls were included as a control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to explore the distribution frequencies of genotypes.
Results. Significant differences were detected between the case group and the control group in the frequencies of the 141T >G and 1349T >G genotypes. At 141T >G, compared with patients carrying the TG + GG genotype, male patients carrying the TT genotype aged more than 20 years with active non-segmental vitiligo, without a family history of vitiligo or other autoimmune diseases, exhibited an increased risk of vitiligo. Binary logistic regression analysis demonstrated that the TT genotype at 141T >G and the non-TT genotype at 1349T >G were independent risk factors for vitiligo development. At 1349T >G, compared with patients carrying the TT genotype, male patients carrying the TG + GG genotype aged more than 20 years with active non-segmental vitiligo, without a family history of vitiligo or other autoimmune diseases, exhibited an increased risk of vitiligo. Moreover, patients carrying 141TG + GG or 1349 TT genotypes had better photochromic effects, lower cumulative radiation doses, shorter treatment times, and earlier first photochromic times.

Key words

vitiligo, APE1, 141T >G, Asp148Glu, risk of vitiligo

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