Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2019, vol. 28, nr 5, May, p. 679–682

doi: 10.17219/acem/94164

Publication type: original article

Language: English

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Antiviral immunity in chronic lymphocytic leukemia measured by anti-rubella antibody

Jadwiga Nowicka1,A,B,C,D,E, Piotr Milejski2,A,C,E,F, Iwona Urbanowicz3,B,C,D, Przemysław Niewiński2,C,D,F

1 Department of Clinical Chemistry, Department of Hematology, Wroclaw Medical University, Poland

2 Department of Clinical Pharmacology, Wroclaw Medical University, Poland

3 Department of Hematology, Wroclaw Medical University, Poland


Background. Chronic lymphocytic leukemia (CLL), the most common form of adult leukemia in Caucasian populations, is characterized by a decrease in anti-infective immunity. Clinical evidence of antiviral immunity decrease is the reactivation of herpes virus in the form of skin lesions. In Europe, rubella infection is common and creates lifelong persistence of IgG antibodies.
Objectives. The aim of our study was to determine whether hemagglutination inhibition (HAI) rubella test can be used to determine antiviral immunity in CLL patients.
Material and Methods. The titers of the HAI test against rubella were examined in a group of 26 healthy subjects, 7 subjects with herpes labialis infection and 56 patients with CLL, among which 9 patients were co-infected with herpes virus.
Results. Statistical tests have shown differences between groups and a significant decrease of the titers of the test in patients with CLL, compared with healthy persons and the herpes group compared with other persons.
Conclusion. Our results indicate a significant decrease of antiviral immunity in patients with CLL and persons with herpes-type skin lesions. Simultaneously, relying on our previous studies, we also suggest that the result of this test may be an important indicator of antiviral immunity in patients with CLL.

Key words

chronic lymphocytic leukemia, herpes, antiviral immunity, rubella HAI test

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