Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2019, vol. 28, nr 3, March, p. 347–353

doi: 10.17219/acem/81538

Publication type: original article

Language: English

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Adropin and irisin: New biomarkers of cardiac status in patients with end-stage renal disease? A preliminary study

Małgorzata Kałużna1,A,B,C,D,F, Krzysztof Pawlaczyk2,A,C,D,E,F, Krzysztof Schwermer2,B,C,D,F, Krzysztof Hoppe2,B,F, Magdalena Człapka-Matyasik3,B,C,D,E,F, Aisha Yusuf Ibrahim2,D,E,F, Nadia Sawicka-Gutaj1,B,E,F, Andrzej Minczykowski4,C,D,E,F, Katarzyna Ziemnicka1,A,C,D,E,F, Andrzej Oko2,E,F, Marek Ruchała1,A,D,E,F

1 Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poland

2 Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, Poland

3 Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poland

4 Department of Cardiology – Intensive Therapy, Poznan University of Medical Sciences, Poland


Background. The new polypeptide hormones adropin and irisin have a broad impact on human metabolism and energy homeostasis. They could be potential biomarkers of cardiac injury. In end-stage renal disease (ESRD), the clinical importance of adropin and irisin is yet to be investigated.
Objectives. The aim of this study was to determine the relationship between these peptides and cardiac status in ESRD patients.
Material and Methods. Seventy-nine ESRD patients on hemodialysis (HD), peritoneal dialysis (PD) or after renal transplantation (Tx), and 40 healthy, ageand sex-matched controls (CON) were included in this study. Serum concentrations of adropin and irisin were measured with enzyme-linked immunosorbent assay (ELISA). Cardiac status was estimated by transthoracic echocardiography and the plasma concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT).
Results. The levels of irisin were significantly lower in HD patients as compared to CON. During HD sessions, the concentrations of adropin did not change significantly, whereas the concentrations of irisin increased with borderline significance. Positive correlations were evident between adropin concentration and cTnT as well as NT-proBNP. Adropin was also correlated with left ventricular systolic internal diameter (LVIDs) (r = 0.375, p = 0.045) and relative wall thickness (RWT) (r = −0.382, p = 0.034). Irisin was correlated with right ventricular diameter (RVd) (r = −0.363, p = 0.045). No correlations were found between irisin and adropin, and blood pressure (BP) measurements.
Conclusion. Adropin could be a new candidate marker of cardiac dysfunction in HD patients. The cause of low levels of irisin found in HD patients is still unclear. These 2 myokines should be further investigated as potential prognostic markers of cardiac status in HD patients.

Key words

hemodialysis, end-stage renal disease, irisin, adropin, cardiac status

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