Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
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Index Copernicus  – 161.11; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2019, vol. 28, nr 10, October, p. 1345–1349

doi: 10.17219/acem/104552

Publication type: original article

Language: English

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The association of serum soluble Klotho levels and residual diuresis and overhydration in peritoneal dialysis patients

Dorota Sikorska1,A,B,C,D,E,F, Krzysztof Pawlaczyk2,A,F, Ewa Baum3,E,F, Maria Wanic-Kossowska2,B,F, Natasza Czepulis4,B,F, Joanna Łuczak2,B,F, Włodzimierz Samborski1,E,F, Andrzej Oko2,A,E,F

1 Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poland

2 Department of Nephrology, Transplantology and Internal Medicine, Poznan University of Medical Sciences, Poland

3 Department of Philosophy and Bioethics, Poznan University of Medical Sciences, Poland

4 Department of Pathophysiology, Poznan University of Medical Sciences, Poland

Abstract

Background. Klotho, originally identified as an anti-aging factor, is a transmembrane protein expressed in the kidney. It has been reported that Klotho deficiency could be associated with a loss of residual renal function and cardiovascular complications in peritoneal dialysis (PD) patients.
Objectives. The main aim of the study was to evaluate whether serum levels of Klotho correlate with residual diuresis and hydration status in PD patients.
Material and Methods. The cross-sectional study involved 57 PD patients ≥18 years of age who had been on PD ≥ 3 months. Serum Klotho was measured using high-sensitivity enzyme-linked immunosorbent assay (ELISA). Hydration status was assessed with bioimpedance analysis (BIA).
Results. Serum levels of soluble Klotho ranged from 100 pg/mL to 700 pg/mL. The patients were divided into 2 subgroups, with Klotho levels below and above the median (260 pg/mL). The data revealed a tendency for lower residual diuresis (1.3 ±1.0 L vs 1.8 ±0.8 L; p = 0.055) in patients with lower levels of Klotho in serum. Serum Klotho correlated negatively with overhydration according to BIA (r = −0.27; p = 0.044) and positively with residual diuresis (r = 0.26; p = 0.045).
Conclusion. Soluble Klotho correlates inversely with hydration status in BIA. Residual urine output, but not dialysis parameters, could be associated with the levels of serum soluble Klotho in PD patients.

Key words

peritoneal dialysis, Klotho, overhydration

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