Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 2, February, p. 245–255

doi: 10.17219/acem/67222

Publication type: review article

Language: English

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Selenium – a fascinating antioxidant of protective properties

Małgorzata Kiełczykowska1,A,B,C,D,E, Joanna Kocot1,C,D,E, Marek Paździor2,B,C,D, Irena Musik1,B,C,D,F

1 Chair and Department of Medical Chemistry, Medical University of Lublin, Poland

2 Traumatic-Orthopaedic and Spine Surgery Ward of Independent Public Health Care Centre, Puławy, Poland


Selenium is a trace element which fulfils important functions in the organism. Its deficit may cause acute disorders, but an overdose can also lead to severe consequences. The functions of selenium in the organism are mainly connected with its antioxidant properties, as it is an essential part of important antioxidant enzymes. Disturbances of oxidant balance have been found to be involved in the activity of numerous harmful factors as well as in the pathogenesis of diverse illnesses. Selenium administration has proved to be effective against the toxicity of many agents and the side effects of drugs. However, the narrow range between therapeutic and toxic doses of selenium, as well as the dependence of its effect on the applied form, dose and method of treatment, makes the choice of the most effective supplement a very complex issue. Divergent forms of selenium are still being studied, including both inorganic and organic compounds as well as Se-enriched natural products. The newest research has also involved selenium nanoparticles. The aim of this review is to present the great potential of selenium for protecting the organism against a wide variety of environmental pollutants, drugs and physical factors.

Key words

oxidative stress, selenium, drug-related side effects, protective agents

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