Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 2, February, p. 225–228

doi: 10.17219/acem/67590

Publication type: original article

Language: English

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New predictor of acute necrotizing pancreatitis: Red cell distribution width

Mehmet Suat Yalçın1,A, Adnan Tas1,F, Banu Kara1,B, Sehmus Olmez1,C, Bunyamin Saritas2,D

1 Department of Gastroenterology, Adana Numune Research and Educational Hospital, Turkey

2 Department of Gastroenterology, Mersin University Medical Faculty, Adana, Turkey


Background. Acute pancreatitis (AP) is inflammation of the pancreas of various severity ranging from mild abdominal pain to mortality. AP may be classified as acute interstitial edematous pancreatitis (AEP) or acute necrotizing pancreatitis (ANP), according to the revised Atlanta criteria. Most of the patients with AP are AEP (75–85% of patients), while 15–25% of patients have ANP. The mortality rate is 3% in AEP and 15% in ANP. Thus, it is important to predict the severity of AP to decrease the morbidity and mortality.
Objectives. The aim of the study was to evaluate the relationship between red cell distribution width (RDW) and the severity of AP on admission to hospital.
Material and Methods. Patients admitted to Adana Numune Research and Educational Hospital with a diagnosis of AP through the time frame of January 2014–May 2016 were included in our study. Diagnosis of AP was made according to the revised Atlanta classification. Patients’ age, sex, etiology of AP, and RDW values were recorded on admission to the hospital.
Results. A total of 180 patients were included in the study. Eighty patients (44%) were male and 100 patients were female. Mean age was 56.25 ±18.3 years (52.66 ±14.4 in males; 59.84 ±20.2 in females). There was no statistically significant difference between patients’ age. The most frequently observed etiologic factor was gallstone disease followed by alcohol intake and the use of pharmaceuticals. Drug-related AP was associated with azathioprine, furosemide, and thiazide diuretics. One hundred forty-four (80%) patients had AEP and 36 (20%) patients had ANP. RDW values showed a statistically significant difference between patients with AEP and ANP (p = 0.011). The cut-off value of RDW was 16.4 and the area under curve (AUC) value was 0.591 (p = 0.0227) with a sensitivity of 29.2% and specificity of 89.83%.
Conclusion. Red cell distribution width could be used to evaluate the prognosis of acute pancreatitis.

Key words

acute pancreatitis, acute necrotizing pancreatitis, red cell distribution width

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