Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
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Index Copernicus  – 161.11; MEiN – 140 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 10, October, p. 1431–1439

doi: 10.17219/acem/73860

Publication type: review article

Language: English

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Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings

Monika Kordyś1,B,C,D,F, Joanna Przeździecka-Dołyk2,3,A,B,C,D,F, Anna Turno-Kręcicka2,E,F, Marta Misiuk-Hojło2,E,F

1 Student, Faculty of Medicine, Wroclaw Medical University, Poland

2 Department and Clinic of Ophthalmology, Faculty of Postgraduate Medicine, Wroclaw Medical University, Poland

3 Department of Optics and Photonics, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Poland


The aim of this study was to summarize the current knowledge of paraneoplastic syndromes involving eyes. The main interest was the immunopathogenesis of the abovementioned entities. A web search was conducted using Medline, Web of Science and Scopus engines. Key words concerning ocular paraneoplastic syndromes (OPS) such as: “ocular paraneoplastic syndrome”, “cancer-associated retinopathy”, “cancer-associated cone dysfunction”, “melanoma-associated retinopathy”, “bilateral diffuse uveal melanocytic proliferation”, and “paraneoplastic optic neuritis” were combined with “immunology”, “immune response”, “antibodies”, or “autoantibodies”. Numerous papers were found as a result of “ocular paraneoplastic syndrome” search and many of them matched the chosen criteria. We focused on the most recent papers – published in the last 5 years – and eventually, 92 items were found. Only several papers from each detailed category fulfilled both OPS and immunologic criteria. Site-specific paraneoplastic syndromes still remain a difficult clinical challenge. The immunopathogenesis of some of them seems to be more complex than previously thought.

Key words

ophthalmologic findings, optic neuropathy, immunopathogenesis, paraneoplastic syndrome, paraneoplastic retinopathy

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