Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
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Index Copernicus  – 161.11; MEiN – 140 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 10, October, p. 1391–1395

doi: 10.17219/acem/70523

Publication type: original article

Language: English

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The importance of serum interleukin-20 levels in patients with Behçet’s disease

Mehmet Emin Enecik1,A,B,C,D,E, Barış Mavi2,A,B,C,E, Çiğdem Yücel3,C,D,E, Göksal Keskin4,A,E,F, Mehmet Yıldız5,B,C

1 Department of Rheumatology, Ankara Numune Training and Research Hospital, Turkey

2 Department of Internal Medicine, Mersin State Hospital, Turkey

3 Department of Clinical Biochemistry, Ankara Numune Training and Research Hospital, Turkey

4 Department of Immunology and Allergy, Medical Faculty, Ankara University, Turkey

5 Department of Internal Medicine, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

Abstract

Background. Behçet’s disease (BD) is a complex multisystemic disease with an unknown origin, which presents with aphthous and genital ulcers, cutaneous lesions, arthritis, ocular lesions, and defects in the gastrointestinal and central nervous systems.
Objectives. In this study, we examined the relationship between serum interleukin-20 (IL-20) levels and disease activity in BD patients.
Material and Methods. A total of 45 BD patients diagnosed according to the BD diagnosis criteria determined by the International Study Group for Behçet’s Disease were included in the study. Out of 45 patients, 17 had inactive BD and 28 had active BD. The control group consisted of 25 healthy subjects. The IL-20 levels of all the groups were detected and compared with each other. Serum IL-20, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were examined.
Results. The IL-20 levels of the active BD patient group were significantly higher than in the control group (p < 0.001) and in the inactive BD patient group (p < 0.001). No statistically significant difference was detected between the IL-20 levels of the control group and the inactive BD patient group (p = 0.2).
Conclusion. Higher IL-20 levels in active BD patients, when compared to inactive BD patients and healthy controls indicate that the disease is an inflammatory one and IL-20 plays a role in the disease pathogenesis. Moreover, it can be concluded that IL-20 might have a role in the complex process of the settlement and activation of the disease.

Key words

cytokines, inflammation, Behçet’s disease, interleukin-20

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