Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
Scopus CiteScore – 3.4 (CiteScore Tracker 3.4)
Index Copernicus  – 161.11; MEiN – 140 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 1, January, p. 119–124

doi: 10.17219/acem/65476

Publication type: original article

Language: English

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Probiotics: Myths or facts about their role in allergy prevention

Edyta Krzych-Fałta1,A,B,D,E, Konrad Furmańczyk1,2,B,C, Aneta Tomaszewska1,A,E, Dominik Olejniczak3,A,E, Bolesław Samoliński1,A,E,F, Urszula Samolińska-Zawisza1,A

1 Department of the Prevention of Environmental Hazards and Allergology, Faculty of Health Sciences, Medical University of Warsaw, Poland

2 Chair of Applied Mathematics, Faculty of Applied Informatics and Mathematics, Warsaw University of Life Sciences, Poland

3 Department of Public Health, Faculty of Health Sciences, Medical University of Warsaw, Poland


Background. The hygiene hypothesis proposed by Strachan in the 1980s clearly emphasized the role of microorganisms in atopy prevention.
Objectives. The study objective was to assess the preventive role of probiotics in patients with allergic rhinitis, bronchial asthma, atopic dermatitis, and/or food allergy.
Material and Methods. The methods used in the study were the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires for 6–7- and 13–14-year-olds and the European Community Respiratory Health Survey II (ECRHS II) questionnaire targeted for the 20–44 age group. The study was conducted as part of the cross-sectional Epidemiology of Allergic Diseases in Poland study conducted in 9 Polish regions (8 urban: Warszawa, Lublin, Białystok, Gdańsk, Poznań, Wrocław, Katowice, Kraków, and the rural regions of Zamojski and Krasnostawski counties). The study material was a group of patients diagnosed with food allergy (n = 407), atopic dermatitis (n = 311), allergic rhinitis (n = 1.353), bronchial asthma (n = 505), and healthy volunteers (n = 2,403).
Results. Genetic factors play an important role in the allergy development. A family history positive for chronic skin disorders increased the risk of atopic dermatitis and food allergies (OR = 1.456, CI = 1.14–1.85, p = 0.002; and OR = 1.378, CI = 1.05–1.81, p = 0.02, respectively). The consumption of products containing live bacterial cultures showed no preventive effects in any of the evaluated disorders in early childhood. Conversely, over the age of 14 years, probiotic formulations exhibit health-promoting effects and may lower the risk of allergic diseases.
Conclusion. The use of probiotics in the Polish population showed no protective effect in the first years of life. The changes in dietary habits introduced during late adolescence demonstrated significantly greater preventive effects of live bacterial cultures against the development of allergic diseases.

Key words

probiotics, prevention, allergy

References (18)

  1. Samoliński B, Raciborski F, Lipiec A, et al. Epidemiologia chorób alergicznych w Polsce. Alergol Pol. 2014;1:10–18.
  2. Nowak A, Śliżewska K, Libudzisz Z, Socha J. Probiotyki – efekty zdrowotne. Żywność Nauka Technologia Jakość (ŻNTJ). 2010;4(71):20–36.
  3. Madonini ER. Probiotics and allergies: Myth or reality? Eur Ann Allergy Clin Immunol. 2014;46(6):196–200.
  4. Bousquet J, Khalataev N, Alvaro A, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008. Alerg Astma Immun. 2008;13(1):3–39.
  5. Roży A, Jaguś P, Chorostowska-Wynimko J. Rola probiotyków w profilaktyce i leczeniu chorób alergicznych. Pneumonol Alergol Pol. 2012;80(1):65–76.
  6. Bjorksten B, Naaber P, Sepp E. Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999;29:342–446.
  7. Feleszko W, Jaworska J, Rha RD, et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy. 2007;37:498–505.
  8. Matsuzaki T, Chin J. Modulating immune responses with probiotic bacteria. Immunol and Cell Biol. 2000;78:67–73.
  9. Fiocchi A, Pawankar R, Cuello-Garcia C, et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P). Probiotics World Allergy Organ J. 2015;8(1):4.
  10. Cuello-Garcia CA, Brożek JL, Fiocchi A, et al. Probiotics for the prevention of allergy: A systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2015;1. pii: S0091-6749(15)00636-3. doi:10.1016/j.jaci.2015.04.031.
  11. Boyle RJ, Ismail IH, Kivivuori S, et al. Lactobacillus GG treatment during pregnancy for the prevention of eczema: A randomized controlled trial. Allergy. 2011;66:509–516.
  12. Loo EX, Shek LP, Goh A, et al. Atopic dermatitis in early life: Evidence for at least three phenotypes? Results from the GUSTO Study. Int Arch Allergy Immunol. 2015;166(4):273–279.
  13. Kurowski M, Kowalski ML. Filagryna i jej rola w patomechanizmie chorób alergicznych. Alerg Astma Immun. 2009;15(2):95–100.
  14. Ponińska J, Samoliński B, Tomaszewska A, et al. Filaggrin gene defects are independent risk factors for atopic asthma in a Polish population: A study in ECAP cohort. PLoS One. 2011;6(2):e16933. doi:10.1371/journal.pone.0016933.
  15. Filipowska-Grońska A, Weryńska-Kalemba M, Bożek A, et al. The frequency of polymorphic variants of filaggrin gene and clinical atopic dermatitis. Adv Dermatol Allergol. 2016;33(1):37–41. doi:10.5114/pdia.2015.48036.
  16. Zajac AE, Adams AS, Turner JH. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis. Int Forum Allergy Rhinol. 2015;5(6):524–532. doi:10.1002/alr.21492.
  17. Giovannini M, Agostoni C, Riva EA, et al. Randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. Pediatr Res. 2007;62(2):215–219.
  18. Wheeler JG, Shema SJ, Bogle ML, et al. Immune and clinical impact of Lactobacillus acidophilus on asthma. Ann Allergy Asthma Immunol. 1997;79(3):229–233.