Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
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Index Copernicus  – 161.11; MEiN – 140 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 1, January, p. 105–110

doi: 10.17219/acem/68234

Publication type: original article

Language: English

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The effect of hemodialysis on intraocular pressure

Ayse Ebru Bahadir Kilavuzoglu1,A,B,C,D,E,F, Gurkan Yurteri2,B,E,F, Nurgul Guven3,B,E,F, Savas Marsap3,B,E,F, Ali Riza Cenk Celebi1,C,E,F, Cemile Banu Cosar1,A,C,E,F

1 Department of Ophthalmology, Acibadem University School of Medicine, Istanbul, Turkey

2 Internal Medicine Clinic, Memorial Sisli Hospital, Istanbul, Turkey

3 Rentek Dialysis Center, Istanbul, Turkey

Abstract

Background. The effect of hemodialysis (HD) on intraocular pressure (IOP) has been investigated before, but there is a lack of consensus. Clinicians dealing with renal failure patients are interested in the potential negative effects of HD on IOP and the course of glaucoma.
Objectives. The aim of this study was to investigate the effects of HD on IOP in patients with end-stage renal disease.
Material and Methods. This prospective study included 106 patients who were receiving outpatient hemodialysis. Patient history of systemic and ophthalmologic conditions was recorded. Serum osmolality (mOsm), blood urea nitrogen (BUN), blood glucose (BG), bicarbonate (BC), and hematocrit (Hct) levels at the start of HD (pre-HD), at the end of HD (end-HD), and 30 min after HD (post-HD) were measured. Systolic and diastolic blood pressures (SBP and DBP) and IOP were measured at pre-HD, 1-hour intervals during HD, end-HD, and post-HD.
Results. A significant decrease in mOsm and BUN and a significant increase in BG, BC, and Hct levels were observed at end-HD (p < 0.05). Mean IOP was 16.71 ±2.51 mm Hg at pre-HD, 15.52 ±3.18 mm Hg at endHD, and 15.23 ±2.73 mm Hg at post-HD (p = 0.001; F = 4.439). Post-HD SBP and DBP were significantly lower than at pre-HD (p < 0.001). There was a positive correlation between the change in IOP and the change in mOsm and the change in BUN at end-HD (r = 0.315, p = 0.004; and r = 0.279, p = 0.012, respectively).
Conclusion. IOP decreased significantly during HD in this study. Additional research on the effects of the change in blood parameters and ocular perfusion pressure on IOP and optic nerve perfusion during HD is recommended.

Key words

glaucoma, hemodialysis, intraocular pressure

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