Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (EN)

Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 9, December, p. 1405–1410

doi: 10.17219/acem/68722

Publication type: original article

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

Biologically active form of vitamin B1 in human peritoneal effluent

Magdalena Jankowska1,A,B,C,D, Monika Lichodziejewska-Niemierko1,C,E,F, Sylwia Małgorzewicz2,B,E,F, Bolesław Rutkowski1,C,E,F

1 Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Poland

2 Department of Clinical Nutrition and Dietetics, Medical University of Gdańsk, Poland

Abstract

Background. Supplementation with vitamin B1 protects the peritoneal membrane from inflammatory and oxidative insults and preserves residual kidney function in rat models of peritoneal dialysis (PD). It is assumed that an active form of vitamin B1, thiamin diphosphate (ThDP), is responsible for this protective effect. However, it has never been shown whether ThDP, a compound known not to cross cellular membranes, is actually detectable in human peritoneal effluent.
Objectives. This study was designed to investigate the concentration, appearance rate, and daily loss of ThDP in the peritoneal effluent of patients treated with PD.
Material and Methods. We performed 24-hour effluent collection as well as the peritoneal equilibration test (PET) and analyzed the relation between the transport characteristics of the peritoneal membrane and appearance rate of ThDP in a cohort of 26 PD patients.
Results. ThDP was detectable in peritoneal effluent in humans. ThDP appearance rate was independent of the transport characteristic of peritoneal membrane, and was not associated with peritoneal transport of other small solutes.
Conclusion. We conclude that ThDP can be found in detectable concentrations in the peritoneal effluent in humans and is transported through the peritoneal membrane in a pattern independent of other small solutes. Our finding opens novel opportunities in further research on the protection of peritoneal membrane in humans.

Key words

peritoneal dialysis, thiamine, micronutrient

References (16)

  1. Manzetti S, Zhang J, van der Spoel D. Thiamin function, metabolism, uptake, and transport. Biochemistry. 2014;53(5):821–835.
  2. Yadav UC, Kalariya NM, Srivastava SK, Ramana KV. Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med. 2010;48(10):1423–1434.
  3. Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012;52(1):182–190.
  4. Kihm LP, Müller-Krebs S, Klein J, et al. Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. J Am Soc Nephrol. 201122(5):914–926.
  5. Boeschoten EW, Schrijver J, Krediet RT, Schreurs WH, Arisz L. Deficiencies of vitamins in CAPD patients: The effect of supplementation. Nephrol Dial Transplant. 1988;3(2):187–193.
  6. Blumberg A, Hanck A, Sander G. Vitamin nutrition in patients on continuous ambulatory peritoneal dialysis (CAPD). Clin Nephrol. 1983;20(5):244–250.
  7. Mydlík M, Derzsiová K, Válek A, Szabó T, Dandár V, Takác M. Vitamins and continuous ambulatory peritoneal dialysis (CAPD). Int Urol Nephrol. 1985;17(3):281–286.
  8. Mydlik M, Derzsiová K. Erythrocyte vitamins B1, B2 and B6 and erythropoietin. Am J Nephrol. 1993;13(6):464–466.
  9. Henderson IS, Leung ACT, Shenkin A. Vitamin status in continuous ambulatory peritoneal dialysis. Perit Dial Bull. 1984;4:143–145.
  10. Skoupy S, Födinger M, Veitl M, et al. Riboflavin is a determinant of total homocysteine plasma concentrations in end-stage renal disease patients. J Am Soc Nephrol. 2002;13(5):1331–1337.
  11. Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr. 1980;33(1):27–39.
  12. Bergström J, Heimbürger O, Lindholm B. Calculation of the protein equivalent of total nitrogen appearance from urea appearance. Which formulas should be used? Perit Dial Int. 1998;18(5):467–473.
  13. Elmadfa I, Majchrzak D, Rust P, Genser D. The thiamine status of adult humans depends on carbohydrate intake. Int J Vitam Nutr Res. 2001;71(4):217–221.
  14. Weber W, Nitz M, Looby M. Nonlinear kinetics of the thiamine cation in humans: Saturation of nonrenal clearance and tubular reabsorption. J Pharmacokinet Biopharm. 1990;18(6):501–523.
  15. Jankowska M, Szupryczyńska N, Dębska-Ślizień A, et al. Dietary intake of vitamins in different options of treatment in chronic kidney disease: Is there a deficiency? Transplant Proc. 2016;48(5):1427–1430.
  16. Bukhari FJ, Moradi H, Gollapudi P, Ju Kim H, Vaziri ND, Said HM. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Nephrol Dial Transplant. 2011;26(7):2137–2144.
© Wroclaw Medical University