Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 8, November, p. 1253–1256

doi: 10.17219/acem/68677

Publication type: original article

Language: English

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Evaluation of aortic intima-media thickness in newborns with Down syndrome

Dilek Sarici1,A,B,C,D,E,F, Selim Kurtoglu2,A,E,F, Serdar Umit Sarici3,C,D,E,F, Ali Yikilmaz4,B, Mustafa Ali Akin2,B, Tamer Gunes2,A,E,F, Mehmet Adnan Ozturk2,A,E,F, Nazmi Narin5,B,F, Munis Dündar6,B, Muhittin Serdar7,C

1 Division of Neonatology, Department of Pediatrics, Keçiören Training and Research Hospital, Ankara, Turkey

2 Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey

3 Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ufuk University, Ankara, Turkey

4 Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

5 Division of Cardiology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey

6 Department of Medical Genetics, Faculty of Medicine, Erciyes University, Kayseri, Turkey

7 Department of Biochemistry, Faculty of Medicine, Acıbadem University, Istanbul, Turkey

Abstract

Background. Health care programs for children with Down syndrome (DS) help improve the overall outcome and quality of life of these children. It is therefore very important to focus on the most common and serious problems of these patients, such as congenital heart defects and cardiac problems, and to keep medical guidelines updated with regard to these problems.
Objectives. The aim of this study was to evaluate aortic intima-media thickness (aIMT), lipid profiles and blood pressure in DS patients in comparison with a control group of ageand gender-matched neonates without DS.
Material and Methods. Serum concentrations of lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglyceride), blood pressure and abdominal aIMT were measured in newborns with DS, and compared with the measurements from ageand gender-matched newborns without DS.
Results. No statistically significant differences between the 2 groups of newborns were detected with respect to aIMT, lipid levels or blood pressure.
Conclusion. This study represents the first investigation of aIMT – one of the most important indicators of atherosclerosis – in DS patients, but neither a significantly increased aIMT, nor any significant changes in lipid profiles or blood pressure were detected in this group of patients. Whether aIMT differs according to the type of congenital heart defect (such as atrial septal defect, ventricular septal defect, patent ductus arteriosus, and atrioventricular septal defect) among DS patients remains to be determined in future studies.

Key words

newborn, Down syndrome, intima-media thickness

References (17)

  1. Jannson U, Johansson C. Down syndrome and celiac disease. J Pediatr Gastroenterol Nutr. 1995;21:443–445.
  2. Sarici D, Akin MA, Kurtoglu S, Gunes T, Ozturk MA, Akcakus M. Thyroid functions of neonates with Down syndrome. Ital J Pediatr. 2012;38:44.
  3. Vis JC, Duffels MG, Winter MM, et al. Down syndrome: A cardiovascular perspective. J Intellect Disabil Res. 2009;53:419–425.
  4. Weijerman ME, van Furth AM, Vonk Noordegraaf A, van Wouwe JP, Broers CJ, Gemke RJ. Prevalence, neonatal characteristics and first-year mortality of Down syndrome: A national study. J Pediatr. 2009;152:15–19.
  5. Yang Q, Rasmussen SA, Friedman JM. Mortality associated with Down’s syndrome in the USA from 1983 to 1997: A population-based study. Lancet. 2002;359:1019–1025.
  6. Roizen NJ, Patterson D. Down’s syndrome. Lancet. 2003;361:1281–1289.
  7. McGill HC Jr, McMahan CA, Herderick EE, et al. Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological determinants of atherosclerosis in youth. Arterioscler Thromb Vasc Biol. 2000;20:836–845.
  8. Koklu E, Ozturk MA, Kurtoglu S, Akcakus M, Yikilmaz A, Gunes T. Aortic intima-media thickness, serum IGF-I, IGFBP-3, and leptin levels in intrauterine growth-restricted newborns of healthy mothers. Pediatr Res. 2007;62:704–709.
  9. Draheim CC, Geijer JR, Dengel DR. Comparison of intima-media thickness of the carotid artery and cardiovascular disease risk factors in adults with versus without the Down syndrome. Am J Cardiol. 2010;106:1512–1516.
  10. Murdoch JC, Rodger JC, Rao SS, Fletcher CD, Dunnigan MG. Down’s syndrome: An atheroma-free model? BMJ. 1977;2:226–228.
  11. Moss TJ, Austin GE. Pre-atherosclerotic lesions in Down syndrome. J Ment Defic Res. 1980;24:137–141.
  12. Yla-Hertmala S, Luoma J, Nikkari T, Kivimaki T. Down’s syndrome and atherosclerosis. Atherosclerosis. 1989;6:269–272.
  13. Salo MK, Solakivi-Jaakkola T, Kivimaki T, Nikkari T. Plasma lipids and lipoproteins in Down’s syndrome. Scand J Clin Invest. 1979;39:485–490.
  14. Simon A, Ludwig CH, Gofman JW, Crook GH. Metabolic studies in mongolism: Serum protein-bound iodine, cholesterol, and lipoprotein. Am J Psychiatry. 1954;111:144–145.
  15. Dalderup LM, Affourtit-Leeuw H, Van der Spek PAF, Keller GHM, Duin HJ, De Iongh H. Serum uric acid and cholesterol levels in mongoloid and nonmongoloid oligophrenics. Br J Psychiatry. 1966;112:91–94.
  16. Nishida Y, Akaoka I, Nishizawa T, Maruki M, Maruki K. Hyperlipidaemia in patients with Down’s syndrome. Atherosclerosis. 1977;26:369–372.
  17. Dorner T, Gaethke AS, Tolksdorf M, Schumann KP, Gustmann H. Cholesterol fractions and triglycerides in children and adults with Down’s syndrome. Clin Chim Acta. 1984;42: 307–311.
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