Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 7, October, p. 1077–1083

doi: 10.17219/acem/64823

Publication type: original article

Language: English

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Correlations between iron content in knee joint tissues and chosen indices of peripheral blood morphology

Barbara Brodziak-Dopierała1,A,C,D,E, Wojciech Roczniak2,B,E,F, Agata Jakóbik-Kolon3,B, Joanna Kluczka3,B, Bogdan Koczy4,B, Jerzy Kwapuliński5,E, Magdalena Babuśka-Roczniak2,B,E

1 Department of Toxicology, Medical University of Silesia, Katowice, Poland

2 Jan Grodek State Vocational Academy, Sanok, Poland

3 Silesian University of Technology, Gliwice, Poland

4 The Dr Janusz Daab District Hospital of Orthopedics and Trauma Surgery, Piekary Śląskie, Poland

5 Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland

Abstract

Background. Iron as a cofactor of enzymes takes part in the synthesis of the bone matrix. Severe deficiency of iron reduces the strength and mineral density of bones, whereas its excess may increase oxidative stress. In this context, it is essential to determine the iron content in knee joint tissues.
Objectives. The study objective was to determine the level of iron in the tissues of the knee joint, i.e., in the femoral bone, tibia and meniscus.
Material and Methods. Material for analysis was obtained during endoprosthetic surgery of the knee joint. Within the knee joint, the tibia, femur and meniscus were analyzed. Samples were collected from 50 patients, including 36 women and 14 men. The determination of iron content was performed with the ICP-AES method, using Varian 710-ES.
Results. The lowest iron content was in the tibia (27.04 μg/g), then in the meniscus (38.68 μg/g) and the highest in the femur (41.93 μg/g). Statistically significant differences were noted in the content of iron in knee joint tissues.
Conclusion. In patients who underwent endoprosthesoplasty of the knee joint, statistically significant differences were found in the levels of iron in various components of the knee joint. The highest iron content was found in the femoral bone of the knee joint and then in the meniscus, the lowest in the tibia. The differences in iron content in the knee joint between women and men were not statistically significant.

Key words

iron, bone tissue, tibia, femur

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