Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 4, July, p. 577–579

doi: 10.17219/acem/62353

PubMed ID: 28691422

Publication type: original article

Language: English

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Hepatitis E virus antibodies in HIV-infected patients and blood donors from western Poland: A preliminary report

Maciej Bura1,A,B,C,D,E,F, Alicja Bukowska2,A,B, Aleksandra Bura3,B,E, Michał Michalak4,C, Iwona Mozer-Lisewska1,A,E,F

1 Department of Infectious Diseases, Hepatology and Acquired Immunodeficiences, Poznan University of Medical Sciences, Poland

2 Regional Blood Center, Poznań, Poland

3 Department of Infectious Diseases, Joseph Strus Multidisciplinary City Hospital, Poznań, Poland

4 Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poland


Background. Hepatitis E virus (HEV) infection is an emerging problem in industrialized countries, including Europe. Little data exists on HEV seroprevalence in Poland.
Objectives. The aim of this study was to assess the prevalence of anti-HEV IgG antibodies in Polish patients infected with the human immunodeficiency virus (HIV) and blood donors.
Material and Methods. Two hundred and ten individuals (n = 105 of HIV-infected patients and n = 105 of ageand sex-matched blood donors from the same area; 178 men and 32 women), aged 18-50 (median age: 38 years), were tested for the presence of anti-HEV IgG antibodies with the EUROIMMUN Anti-Hepatitis E Virus (HEV) ELISA (IgG) tests (Lübeck, Germany). Additionally, some simple clinical and laboratory data was collected.
Results. The overall anti-HEV IgG prevalence was 2.4% (5/210). One HIV-positive patient (0.95%) and 4 blood donors (3.8%) were seropositive (p = 0.1745). All the HEV-exposed individuals were men with a history of travel abroad and no icteric disease in the past.
Conclusion. Exposure to HEV infection among Polish HIV patients and blood donors seems to be uncommon. Data on this issue is scarce and conflicting for HIV-infected individuals. Further investigations applying different serological tests and concomitant HEV RNA testing are needed to reliably assess the risk and practical impact of HEV infection in Poland.

Key words

HIV, seroprevalence, blood donors, HEV

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