Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 4, July, p. 563–569

doi: 10.17219/acem/62536

PubMed ID: 28691424

Publication type: original article

Language: English

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An animal model of the procognitive properties of cysteine protease inhibitor and immunomodulatory peptides based on colostrum

Bartłomiej Stańczykiewicz1,A,B,C,D,F, Marta Jakubik-Witkowska1,B,C,D, Antoni Polanowski2,A,D,E, Tadeusz Trziszka2,A,F, Joanna Rymaszewska1,A,E,F

1 Division of Consultation Psychiatry and Neuroscience, Department of Psychiatry, Wroclaw Medical University, Poland

2 Department of Animal Products Technology and Quality Management, University of Environmental and Life Sciences, Wrocław, Poland

Abstract

Background. The positive effect of human cystatin C on the development of Alzheimer’s disease has been reported, as it inhibits the formation of β-amyloid oligomers and amyloidogenesis. Cystatin C has been found to have a neuroprotective effect by inhibiting cysteine proteases, inducing autophagy and neurogenesis. There is a growing interest in the procognitive properties of colostrum-based specimens, which could delay dementia and ameliorate memory deterioration.
Objectives. The aim of the study was to evaluate the influence of ovocystatin and a Coloco peptide complex on the cognitive functions in reference to Colostrinin, using a model of young (4 month-old) and old (10-month-old) Wistar rats.
Material and Methods. In the present study, the effects of ovocystatin [100 μg/rat] and the Coloco peptide [4 μg/rat]derived from colostrum were assessed with respect to the reference specimen, Colostrinin [4 μg/rat]. The specimens were administered intraperitoneally and orally for 12 days. Cognitive functions were assessed using the Morris water maze (MWM).
Results. The group of young rats that received ovocystatin orally obtained significantly better results in the MWM compared to the placebo group (p < 0.05). Similarly, the group of young rats receiving Coloco orally obtained better results in the MWM compared to the placebo group and to the group of rats receiving Colostrinin (p < 0.05). There were no statistically significant differences in the oral and intraperitoneal administration of ovocystatin, Coloco and Colostrinin in the group of old rats.
Conclusion. The obtained results suggest that oral administration of ovocystatin and Coloco has beneficial effects on the cognitive functions of young rats.

Key words

ovocystatin, Coloco, Colostrinin (cln), Morris water maze, cognitive decline

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