Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 3, May-June, p. 539–547

doi: 10.17219/acem/67461

Publication type: review article

Language: English

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The role of human papillomavirus in oncogenic transformation and its contribution to the etiology of precancerous lesions and cancer of the larynx: A review

Katarzyna Nowińska1,B,C,D, Urszula Ciesielska1,C,D, Marzenna Podhorska-Okołów1,E, Piotr Dzięgiel1,2,A,E,F

1 Departament of Histology and Embriology, Wroclaw Medical University, Poland

2 Department of Physiotherapy, Wroclaw University School of Physical Education, Poland


Human papillomavirus (HPV) belongs to the Papillomaviridae family and infects squamous cells and mucous membranes of humans. Various studies conducted over the last years have shown a correlation between HPV infection and carcinogenesis process. The DNA of the virus is detected in approximately 20% of cancers of the upper respiratory tract. The presence of HPV in cancerous lesion of the larynx varies depending on the procedure applied for sample collection and the viral DNA detection method. The high variance in the frequency of HPV detection is observed even among results obtained with the use of PCR reaction. It varies between 3 and 85%. HPV is also the etiological factor of laryngeal papillomas in both children and adults. However, a considerable amount of research demonstrates that 1-7% of the larynx papillomas in adults undergo transformation into squamous cell carcinoma. The aim of the study was to summarize the current state of knowledge regarding the presence of the HPV virus in the larynx as well as its participation in malignant transformation.

Key words

human papillomavirus, larynx cancer, laryngeal papillomatosis, laryngeal neoplasm, tumorigenic transformations

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