Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Index Copernicus  – 161.11; MEiN – 140 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 2, March-April, p. 327–332

doi: 10.17219/acem/58782

Publication type: original article

Language: English

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Neutrophil CD64 as a diagnostic marker for neonatal sepsis: Meta-analysis

Ji Dai1,B,C, Wenjie Jiang2,B,D, Zhigang Min3,B,E, Jian Yang4,B,E, Yongfei Tan5,F, Tieliang Ma6,E,F, Zhijun Ge1,A,E,F

1 Department of Critical Care Medicine, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China

2 Department of Anesthesiology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China

3 Department of Radiology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China

4 Department of Oncology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China

5 Department of Cardiac & Thoracic Surgery, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China

6 Central Laboratory, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China


Background. Neutrophil CD64 (nCD64) is a promising marker for diagnosing bacterial infections. Several studies have investigated the performance of nCD64 for diagnosing neonatal sepsis and the results are variable. Interest in nCD64 for detecting serious bacterial infections is increasing rapidly.
Objectives. The aim of the present study was to carry out a meta-analysis to systematically evaluate the diagnostic accuracy of nCD64 in neonatal sepsis. As far as the authors know, no previous studies have undertaken this.
Material and Methods. A review of studies from Pubmed, Embase and the Cochrane Library, from inception through June 2015, found 7 studies (involving 2213 neonates) fulfilling the inclusion criteria. These 7 studies were subjected to a bivariate meta-analysis of sensitivity and specificity and a summary receiveroperating characteristic (SROC) curve; I2 was used to test heterogeneity, and the source of heterogeneity was investigated by influence analysis and meta-regression.
Results. The pooled sensitivity and specificity were 80% (95%CI, 69–88%) and 83% (95%CI, 71–90%), respectively. The area under the SROC curve (AUC) was 0.88 (95%CI, 0.85–0.91). The studies had substantial heterogeneity (I2 = 87.1%).
Conclusion. The results showed that nCD64 is a reliable biomarker for diagnosing neonatal sepsis (AUC = 0.88).

Key words

meta-analysis, neonatal infection, CD64, neonatal sepsis

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