Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2017, vol. 26, nr 1, January-February, p. 77–82

doi: 10.17219/acem/61003

Publication type: original article

Language: English

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Relationship of lipoprotein lipase gene variants and fasting triglyceride levels in a pediatric population: The CASPIAN-III study

Roya Kelishadi1,A,B,C,D,E,F, Mahin Hashemipour2,A,B,D,F, Behnoosh Esteki1,A,B,D,F, Mohammad Hasan Tajadini3,A,B,C,D,E,F, Laleh Rafiei3,A,B,C,D,E,F, Mohammad Esmaeil Motlagh4,A,B,D,F, Golnaz Vaseghi3,A,B,C,D,E,F, Gelayol Ardalan1,A,B,D,F, Shaghayegh Haghjooy Javanmard3,A,B,D,F

1 Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

2 Alzahra Hospital, Pediatrics Department, School of Medicine, Isfahan University of Medical Sciences, Iran

3 Physiology Department, Applied Physiology Research Center, Isfahan University of Medical Sciences, Iran

4 Pediatrics Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Background. Lipoprotein lipase (LPL) is one of the major enzymes responsible for the hydrolysis of triglyceride (TG)-rich lipoprotein. The effects of LPL polymorphisms on serum TG are inconsistent among different populations.
Objectives. This study aims to assess the TG serum concentration and distributions of three LPL single nucleotide polymorphisms (SNPs), namely D9N, HINDIII and S447X, in a nationally representative sample of Iranian adolescents.
Material and Methods. We studied the associations between SNP genotypes and TG levels in a nationally representative sample of Iranian adolescents. Genotyping was performed in 750 randomly selected participants. We compared the genotypes according to different TG levels.
Results. This study comprised 746 participants, with mean ± SD age of 14.6 ± 2.5 years. The distribution of genotypes of D9N and S447X were not significantly different according to TG levels. Regarding the HINDIII polymorphism, the distribution of GG, GT, and TT genotypes were significantly different in participants with low, borderline-high, and elevated TG (p = 0.02, 0.03, and 0.01, respectively). The mean TG was not significantly different according to the genotype distribution.
Conclusion. In this study, most of the LPL gene variants were not significantly different in adolescents with normal and elevated TG, and the mean TG was not different in participants with various genotypes. As the first evidence from the pediatric population of the region of the Middle East and North Africa (MENA), these results might be used in international comparisons. Our findings might suggest that the high prevalence of hypertriglyceridemia in Iranian adolescents is more likely to be a result of lifestyle rather than genetic factors.

Key words

single nucleotide polymorphisms, adolescence, triglycerides, lipoprotein lipase

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