Advances in Clinical and Experimental Medicine
2017, vol. 26, nr 1, January-February, p. 57–61
Publication type: original article
Induction and maintenance infliximab therapy in children with moderate to severe ulcerative colitis: Retrospective, multicenter study
1 2nd Department of Paediatrics, Gastroenterology and Nutrition, Wroclaw Medical University, Poland
2 Children’s Memorial Health Institute, Warsaw, Poland
3 Department of Pediatric Gastroenterology and Metabolic Disorders, Poznan University of Medical Science, Poland
4 Department of Pediatrics, Medical University of Silesia, Gastroenterology Unit, Upper Silesian Child Health Care Center, Katowice, Poland
5 Pediatric Nursery Unit of Pomeranian Medical University, Division of Pediatrics, Gastroenterology and Reumatology of Zdroje Hospital, Szczecin, Poland
6 Department of Pediatrics, State Hospital no. 2, Rzeszów, Poland
7 Province Children’s Hospital, Kielce, Poland
Background. Pediatric ulcerative colitis (UC) is a severe disease characterised by the presence of extensive inflammatory lesions in the colon. The administration of intravenous corticosteroids is recommended in patients with acute relapse of the disease, whereas early treatment with cyclosporine, tacrolimus or infliximab is recommended if there is no improvement.
Objectives. The aim of this study was to retrospectively evaluate the efficacy and safety of infliximab therapy in the treatment of moderate-to-severe and severe relapse of pediatric UC.
Material and Methods. The analysis included 42 children aged 4–18 years (23 girls, 19 boys) treated in 7 pediatric gastroenterology departments in Poland during the past 4 years. The disease duration ranged from 2 to 100 months. The clinical activity of UC ranged from 35 to 85 points according to the PUCAI scale. Twenty-one children were diagnosed with pancolitis, 10 children with extensive UC, and the remaining with the left-sided UC. In the induction therapy infliximab was administered at doses of 5 mg/kg in the 0.2 and 6 weeks, and after the clinical response every 8 weeks to 12 months. Treatment results were assessed in 10 and 54 weeks.
Results. After the induction therapy the clinical response was achieved in 14 children (33.33%) and clinical remission in 11 children (26.19%). Two children required surgical treatment, and the remaining 2 suffered from anaphylactic shock. After the maintenance therapy clinical remission was maintained in 12 children (57.14%), whereas 3 children required surgery (colectomy).
Conclusion. Infliximab therapy in children with moderate-to-severe UC induces remission and, in some children, proves to be effective in preventing early colectomy.
children, infliximab, ulcerative colitis
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