Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2016, vol. 25, nr 6, November-December, p. 1207–1213

doi: 10.17219/acem/62455

Publication type: original article

Language: English

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Impact of Birth Weight and Smoking on Lung Function in Patients with Asthma, COPD, and Healthy Volunteers

Bernard Panaszek1,A,D,F, Robert Pawłowicz1,B, Karolina Lindner1,B, Rafał Dobek1,E, Konrad Panaszek2,B, Andrzej Obojski1,C, Joanna Rosińczuk1,E,F, Jerzy Ichnowski3,A

1 Department of Internal Medicine and Allergology, Wroclaw Medical University, Poland

2 Gedeon Richter Marketing, Warszawa, Poland

3 Non-public Health Care Center “MEDICUS”, Lubsko, Poland

Abstract

Background. Birth weight (BW) is an important factor for determining the development of the respiratory system. The majority of research analyzed the impact of BW on lung function in youth. BW influence and smoking on lung function in adults with asthma and COPD is an interesting issue.
Objectives. The aim of the study was to investigate relationships between BW, smoking, and lung function in adult healthy individuals and diagnosed with asthma or COPD.
Material and Methods. Four hundred seventy-nine subjects were divided into 5 groups: 123 healthy non-smokers, 180 healthy smokers, 72 non-smoking asthmatics, 57 smoking asthmatics, and 47 COPD patients. Relationships between 4 BW quartiles and lung function was analyzed with respect to smoking.
Results. Impact analyzes of BW, smoking, and asthma on FVC% revealed that asthma is the only significant differentiating factor in this spirometric parameter (p < 0.01). FEV1% was significantly influenced by asthma and BW, and FEV1/ FVC% was exclusively influenced by asthma. Spirometric parameters increased proportionally to particular BW quartiles in healthy non-smokers group; however optimal BW quartile predicting increase of parameters was 2751–3250 g. In asthma, BW quartile predicting the increase of spirometric parameters was 3251–3750 g, but BW quartile predicting decrease of FEV1/FVC% was 2751–3250 g. The comparison of results between COPD group and results from other 4 groups showed that values of all parameters in patients with COPD did not change proportionally to all quartiles of BW. In terms of FEV1/FVC%, the proportional increase of parameter in BW quartile 2751–3250 g was observed.
Conclusion. BW, as independent factor influences on spirometric parameters of healthy individuals, patients with asthma, COPD in a differentiated manner depending on quartile of BW rather than on simple linear increase of BW, regardless of smoking.

Key words

asthma, smoking, COPD, lung function, birth weight

References (21)

  1. Kotecha SJ, Watkins WJ, Henderson AJ, Kotecha S: The effect of birth weight on lung spirometry in white, school-aged children and adolescents born at term: A longitudinal population based observational cohort study. J Pediatr 2015, 166, 1163–1167.
  2. Vom Hove M, Prenzel F, Uhlig HH, Robel-Tillig E: Pulmonary outcome in former preterm, very low birth weight children with bronchopulmonary dysplasia: A case-control follow-up at school age. J Pediatr 2014, 164, 40–45.
  3. Fauroux B, Gouyon JB, Roze JC, Guillermet-Fromentin C, Glorieux I, Adamon L: Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: A 12-month follow-up of the CASTOR study cohort. Epidemiol Infect 2014, 142, 1362–1374.
  4. Seidman DS, Laor A, Gale R, Stevenson DK, Danon YL: Is low birth weight a risk factor for asthma during adolescence? Arch Dis Child 1991, 66, 584–587.
  5. Steffensen FH, Sorensen HT, Gillman MW, Rothman KJ, Sabroe S, Fischer P: Low birth weight and preterm delivery as risk factors for asthma and atopic dermatitis in young adult males. Epidemiology 2000, 11, 185–188.
  6. Wjst M, Popescu M, Trepka MJ, Heinrich J, Wichmann HE: Pulmonary function in children with initial low birth weight. Pediatr Allergy Immunol 1998, 9, 80–90.
  7. Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R: Interpretative strategies for lung function tests. Eur Respir J 2005, 26, 948–968.
  8. Hyde I, English RE, Williams JD: The changing pattern of chronic lung disease of prematurity. Arch Dis Child 1989, 64, 448–451.
  9. Verma RP, Chandra S, Niwas R, Komaroff E: Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants. J Perinatol 2006, 26, 197–200.
  10. Berk DR, Varich LJ: Localized persistent pulmonary interstitial emphysema in a preterm infant in the absence of mechanical ventilation. Pediatr Radiol 2005, 35, 1243–1245
  11. Joseph-Bowen J, de Klerk NH, Firth MJ, Kendall GE, Holt PG, Sly PD: Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. Am J Respir Crit Care Med 2004, 169, 850–854.
  12. Connolly CK, Prescott RJ: The Darlington and Northallerton long term asthma study: Pulmonary function. BMC Pulm Med 2005, 5, 2.
  13. Peat JK, Woolcock AJ, Cullen K: Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 1987, 70, 171–179.
  14. Kupczyk M, Kuprys-Lipinska I, Gorski P, Kuna P: Long-term deterioration of lung function in asthmatic outpatients. Respiration 2004, 71, 233–240.
  15. Bakke PS. Factors affecting growth of FEV1. Monaldi Arch Chest Dis 2003, 59, 103–107.
  16. Lodrup Carlsen KC, Magnus P, Carlsen KH: Lung function by tidal breathing in awake healthy newborn infants. Eur Respir J 1994, 7, 1660–1668.
  17. Sheldon RL: Pulmonary function testing. Clinical assessment in respiratory care. RL Wilkins, RL Sheldon, SJ Krider editors. Elsevier Mosby, St Louis 2005, 141–164.
  18. Lum S, Hoo AF, Hulskamp G, Wade A, Stocks J: Potential misinterpretation of infant lung function unless prospective healthy controls are studied. Pediatr Pulmonol 2010, 45, 906–913.
  19. Von Ungern-Sternberg BS, Regli A, Reber A, Schneider MC: Comparison of perioperative spirometric data following spinal or general anaesthesia in normal-weight and overweight gynaecological patients. Acta Anaesthesiol Scand 2005, 49, 940–948.
  20. Parra A, Sanz ML, Vila L, Prieto I, Dieguez I, Oehling AK: Eosinophil soluble protein levels, eosinophil peroxidase and eosinophil cationic protein in asthmatic patients. J Investig Allergol Clin Immunol 1999, 9, 27–34.
  21. Ong KC, Wang YT: Factors associated with improvement in breathing capacity during exercise in patients with chronic obstructive pulmonary disease. Respirology 2003, 8, 332–338.