Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2016, vol. 25, nr 4, July-August, p. 643–648

doi: 10.17219/acem/41191

Publication type: original article

Language: English

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Comparable Function of γ-Tocopherols in Asthma Remission by Affecting Eotaxin and IL-4

Yan-Mei Wu1,A, Zhi-Wen Xue1,B, Li-Li Zhang1,C, Ning-Mei Gao1,C, Xiao-Mei Du1,D, Xiao-Yan Zhang1,D, Zhuo-Hong Zhang1,C, Zhi-Guo Zhang1,B

1 Department of Respiratory and Blood Oncology, Xi’An XD Group Hospital, ShaanXi, Xi’an, China

Abstract

Background. Bronchial asthma is one of the world’s most common chronic disorders dangerous to human health. It has been hypothesized that the increased number of asthma sufferers may be due to changing antioxidant intake or vitamin deficiency. However, the influence of vitamins on asthma has rarely been considered.
Objectives. The aim of this study was to explore the effects of γ-tocopherols, a specific form of vitamin E, on asthma remission together with the possible mechanism behind the process.
Material and Methods. Eosinophil counting was applied to detect the total number of cells, eosinophils and lymphocytes. Meanwhile, HE staining was used for morphological detection. In addition, the eotaxin and IL-4 levels in the serum and bronchoalveolar lavage fluid were measured using ELISA technology.
Results. The cell counting results showed that γ-tocopherols possesses the capability to reduce the number of eosinophils. Moreover, the exudation of inflammatory cells together with the hyperplasia of goblet cells was also found to experience significant inhibition when treated with γ-tocopherols. Furthermore, the high levels of eotaxin and IL-4 in the asthma group were evidently reduced under the treatment of γ-tocopherols which was comparable with hexadecadrol.
Conclusion. γ-tocopherols can remit asthma by regulating the level of eotaxin and IL-4. Moreover, γ-tocopherols may be regarded as a potential candidate for asthma treatment after much deeper explorations.

Key words

asthma, γ-tocopherols, dexamethasone, eotaxin, IL-4

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