Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2016, vol. 25, nr 3, May-June, p. 449–455

doi: 10.17219/acem/35639

Publication type: original article

Language: English

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Adiponectin and Cardiac Hypertrophy in Acromegaly

Sabriye Gurbulak1,B, Fulya Akin2,A,C,D,E, Emrah Yerlikaya3,D, Guzin F. Yaylali2,C,E, Senay Topsakal2,B, Halil Tanriverdi4,B, Beyza Akdag5,C, Bunyamin Kaptanoglu6,B

1 Department of Internal Medicine, Pamukkale University, Turkey

2 Department of Endocrinology, Pamukkale University, Turkey

3 Department of Endocrinology, Denizli State Hospital, Turkey

4 Department of Cardiology, Pamukkale University, Turkey

5 Department of Biostatistics, Pamukkale University, Turkey

6 Department of Biochemistry, Pamukkale University, Turkey

Abstract

Background. Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.
Objectives. The aim of this study was to find out how adiponectin levels were affected in acromegalic patients and the relationship between adiponectin levels and cardiac parameters.
Material and Methods. We included 30 subjects (15 male, 15 female), diagnosed with acromegaly and 30 healthy (10 male, 20 female) subjects. Serum glucose, insulin, GH, IGF-1 and adiponectin levels were obtained and the insulin resistance of the subjects was calculated. Echocardiographic studies of the subjects were performed.
Results. We determined that adiponectin levels were significantly higher in the acromegalic group than the control group. In the acromegalic group, there was no statistically significant relation between serum adiponectin and growth hormone (GH), or insulin-like growth factor-1 (IGF-1) levels (p = 0.3, p = 0.1). We demonstrated that cardiac function and structure are affected by acromegaly. IVST, PWT, LVMI, E/A ratio, DT, ET, IVRT, VPR, and LVESV values were increased and the results were statistically significant. In the acromegalic group, adiponectin levels were positively related with left ventricle mass index (LVMI) but this correlation was found to be statistically weak (p = 0.03). In our study, there was a positive correlation between VAI and LVM. We also could not find any correlation between VAI and adiponectin levels.
Conclusion. Although insulin resistance and high insulin levels occur in active acromegaly patients, adiponectin levels were higher in our study as a consequence of GH lowering therapies. Our study showed that adiponectin levels may be an indicator of the cardiac involvement acromegaly. However, the usage of serum adiponectin levels in acromegalic patients as an indicator of cardiac involvement should be supported with other, wide, multi-centered studies.

Key words

acromegaly, insulin resistance, cardiac hypertrophy, echocardiography, adiponectin

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