Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 6, November-December, p. 1113–1117

doi: 10.17219/acem/50572

Publication type: review article

Language: English

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Mycotic Infections of the Eye

Mirosław Słowik1,A,D, Monika M. Biernat2,3,B,D, Donata Urbaniak-Kujda3,B,E, Katarzyna Kapelko-Słowik3,A,B,D, Marta Misiuk-Hojło1,F

1 Department and Clinic of Ophthalmology, Wroclaw Medical University, Poland

2 Department of Microbiology, Wroclaw Medical University, Poland

3 Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Poland


Fungal infections of the eye are an important cause of significant visual loss and blindness in some regions of the world, especially developing countries. Ocular mycoses remain a diagnostic and therapeutic challenge to the ophthalmologist. Corneal infection is the most frequent presentation, but the orbit, eyelids, lacrimal apparatus, conjunctiva, sclera and internal structures of the eye can also be affected. Candida spp., Fusarium spp. and Aspergillus spp. are the most frequently isolated organisms in fungal keratitis and in endophthalmitis. The difficulties posed by ocular mycoses are mainly related to establishing the clinical diagnosis, isolation of the fungal pathogen and effective local treatment, particularly in infections of the cornea. The critical issue in diagnosing fungal infection of the eye is microbiological identification of the etiologic agent in clinical samples. Early diagnosis and prompt treatment allow serious complications, including blindness, to be avoided. Local, systemic and even surgical treatment is applied in the therapy.

Key words

ocular mycoses, fungal keratitis, antifungal drugs

References (25)

  1. Ayse K, Sengul O: Ocular Fungal Infections. Curr Eye Res 2011, 36, 179–189.
  2. Doorenbos-Bot AC, Hooymans JM, Blanksma LJ: Periorbital necrotising fasciitis due to Cryptococcus neoformans in a healthy young man. Doc Ophthalmol 1990, 75, 315–320.
  3. Ganne P, Babu R, Mohan Girija G: Conjunctival rhinosporidiosis. JAMA Ophthalmol 2015, Jan, 133, 39.
  4. Duncan K, Jeng BH: Medical management of blepharitis. Curr Opin Ophthalmol 2015, 26, 289–294.
  5. Cruz AA, Zenha F, Silva JT Jr, Martinez R: Eyelid involvement in paracoccidioidomycosis. Ophthal Plast Reconstr Surg 2004, 20, 212–216.
  6. Różycki R, Rekas M, Wiśniewski P: Mycotic lacrimal canaliculitis – cases report. Klin Oczna 2004, 106, 338–342.
  7. Behrens-Baumann W: Mycoses of the eye and its adnexa. Dev Ophthalmol 1999, 32, 27–107.
  8. Ghose S, Mahajan VM: Fungal flora in congenital dacryocystitis. Indian J Ophthalmol 1990, 38, 189–190.
  9. Philips R, Adamski Z: Zakażenia grzybicze oka. W: Mikologia lekarska dla lekarzy i studentów. Wyd. Nauk. Uniwersytetu Medycznego, Poznań 2007, 2nd ed., 236–248.
  10. Suh LH, Barron J, Dubovy SR, Gaunt ML, Ledee DR, Miller D, Fell JW, Forster RK: Ocular rhinosporidiosis presenting as chronic follicular conjunctivitis in a contact lens wearer. Arch Ophthalmol 2009, 127, 1076–1077.
  11. Marshall DH, Brownstein S, JacksonWB: Post-traumatic corneal mucormycosis caused by Absidia corymbifera. Ophthalmology 1997, 104, 1107–1111.
  12. Borderie VM, Bourcier TM, Poirot JLP: Endophthalmitis after Lasiodiplodia theobromae corneal abscess. Graefe’s Arch Clin Exp Ophthalmol 1997, 235, 259–261.
  13. Fincher T, Fulcher SF: Diagnostic and therapeutic challenge of Aspergillus flavus scleritis. Cornea 2007, 26, 618–620.
  14. Khater MM, Shehab NS, El-Badry AS: Comparison of mycotic keratitis with nonmycotic keratitis: an epidemiological study. J Ophthalmol 2014, 2014, 254302. DOI: 10.1155/2014/254302. Epub 2014 Dec 7.
  15. Rosa RH, Miller D, Alfonso EC: The changing spectrum of fungal keratitis in South Florida. Ophthalmology 1994, 101, 1005–1013.
  16. Kański JJ, Bowling B: Okulistyka kliniczna. Elsevier Uraban & Partner, Wrocław, 2013, 4th ed.
  17. Nielsen JS, Fick TA, Saggau DD, Barnes CH: Intravitreal anti–vascular endothelial growth factor therapy for choroidal neovascularization secondary to ocular histoplasmosis syndrome. Retina 2012, 32, 468–472.
  18. Lamaris GA, Esmaeli B, Chamilos G: Fungal endophthalmitis in a tertiary care cancer center: A review of 23 cases. Eur J Clin Microbiol Infect Dis 2008, 27, 343–347.
  19. Mody KH, Ali MJ, Vemuganti GK, Nalamada S, Naik MN, Honavar SG: Orbital aspergillosis in immunocompetent patients. Br J Ophthalmol 2014, 98, 1379–1384.
  20. Breit SM, Hariprasad SM, Mieler WF: Management of endogenous fungal endophthalmitis with voriconazole and caspofungin. Am J Ophthalmol 2005, 139, 135–140.
  21. Silva RA, Sridhar J, Miller D, Wykoff CC, Flynn HW Jr: Exogenous fungal endophthalmitis: an analysis of isolates and susceptibilities to antifungal agents over a 20-year period (1990–2010). Am J Ophthalmol 2015, 159, 257–264.
  22. Riddell J, Comer GM, Kauffman CA: Treatment of Endogenous Fungal Endophthalmitis: Focus on New Antifungal Agents. Clin Infect Dis 2011, 52, 648–653.
  23. Mohamed MS, Abdel-Motaleb HY, Mobarak FA: Management of rhino-orbital mucormycosis. Saudi Med J 2015, 36, 865–868.
  24. Chahal HS, Abgaryan N, Lakshminarayanan R, Glover AT: Orbital Mucormycosis Following Periorbital Cutaneous Infection. Ophthal Plast Reconstr Surg 2015, Apr 7 [Epub ahead of print].
  25. Dzierżanowska D, Dzierżanowska-Fangrat K: Przewodnik terapii inwazyjnych zakażeń grzybiczych. α-medica Press, Bielsko-Biała 2010, 50–53.