Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 4, July-August, p. 623–627

doi: 10.17219/acem/47735

Publication type: original article

Language: English

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Relationship Between Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Obstructive Sleep Apnea Syndrome

Sabri Koseoglu1,A,B,C,D,E,F, Kursat M. Ozcan1,A,B,C,D,E,F, Aykut Ikinciogullari1,A,B,C,D,E,F, Mehmet A. Cetin1,A,B,C,D,E,F, Erol Yildirim2,A,B,C,D,E,F, Huseyin Dere1,A,B,C,D,E,F

1 Ankara Numune Education and Research Hospital, ENT Clinic, Turkey

2 Kars State Hospital, ENT Clinic, Turkey


Background. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) give information about many diseases. An increase in inflammation markers occurs in patients with obstructive sleep apnea syndrome (OSAS).
Objectives. The aim of this study is to determine the relationship between OSAS and NLR and PLR values.
Material and Methods. Two hundred eighty four patients with complaints of snoring and excessive daytime sleepiness were included in the study. Polysomnography had been performed on all patients and the control group. Fourty eight of these patients with apnea-hypopnea index (AHI) less than 5 (pure snoring) were included in the control group, 67 patients with AHI between 5 and 14.9 in the mild OSAS group, 61 patients with AHI between 15 and 29.9 in the moderate OSAS group and 108 patients with AHI more than 30 in the severe OSAS group. NLR and PLR values were calculated from the complete blood count (CBC) analysis of the patients and control group. The OSAS and control groups were compared by age, gender, body mass index (BMI) and PSG parameters as well as NLR and PLR values.
Results. The PLR value in the OSAS group was found to be less than in the control group (p = 0.006). As the non-REM AHI increased, the value of PLR decreased. As the nocturnal time spent with arterial oxygen saturation < 90% increased, the value of NLR was determined to increase.
Conclusion. NLR and PLR values can give valuable information in OSAS.

Key words

obstructive sleep apnea, neutrophil, lymphocyte, inflammation.

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