Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 3, May-June, p. 531–535

doi: 10.17219/acem/31805

Publication type: review article

Language: English

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Caspase-Dependent Apoptosis of Retinal Ganglion Cells During the Development of Diabetic Retinopathy

Joanna Adamiec-Mroczek1,D, Hanna Zając-Pytrus1,E, Marta Misiuk-Hojło1,F

1 Department of Ophthalmology, Wroclaw Medical University, Poland

Abstract

Diabetic retinopathy constitutes the most frequent cause of vision loss in professionally active individuals. Progressive impairment of visual acuity results from massive fibrovascular proliferation involving the fundus of the eye, as well as from the apoptosis of the neuronal structures of the retina. The results of many clinical studies, both on experimental models and on human material, confirmed evident enhancement of this process in the course of diabetes. The programmed cell death of retinal ganglion cells predominantly occurs secondarily to caspase-dependent intracellular processes. This paper presents evidence for the considerable involvement of the caspase-dependent mechanism of apoptosis of retinal ganglion cells in the early stages of retinal changes associated with progressive impairment of visual acuity. The authors emphasize the necessity of comprehensive understanding of mechanisms that underlie the programmed death of neural cells in the eyes of patients with diabetes. This clinical problem becomes of vital importance in view of the constantly increasing incidence of diabetes and severe impairment associated with the disorders of carbohydrate metabolism. Identification of a key component involved in this process would enable attempts oriented at pharmacological blockade of apoptosis in the retinal ganglion cells of patients with diabetes.

Key words

apoptosis, retinal ganglion cells, diabetic retinopathy, caspase.

References (31)

  1. Li YH, Zhuo YH, Lu L, Chen NY, Huang XH, Zhang JL, Li SY, Wang XG: Caspase dependent retinal ganglion cell apoptosis in the rat model of acute diabetes. Chin Med 2008, 121, 2566–2571.
  2. Yang Y(1), Mao D, Chen X, Zhao L, Tian Q, Liu C, Zhou BL: Decrease in retinal neuronal cells in streptozotocininduced diabetic mice. Mol Vis 2012, 18, 1411–1420.
  3. Borrie SC, Duggan J, Cordeiro MF: Retinal cell apoptosis. Expert Rev Ophthalmol 2009, 4, 27–45.
  4. Vujosevic S(1), Midena E: Retinal layers changes in human preclinical and early clinical diabetic retinopathy support early retinal neuronal and Müller cells alterations. J Diabetes Res 2013, 2013, 905058 2013, 2013, 905058.
  5. Yang JH, Kwak HW, Kim TG, Han J, Moon SW, Yu SY: Retinal Neurodegeneration in Type II Diabetic Otsuka Long-Evans Tokushima Fatty Rats. IOVS 2013, 54, 3844–3851.
  6. Barber A, Gardner T, Abcouwer S: The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy. IOVS 2011, 52, 1156–1163.
  7. Korzeniewska-Dyl I: Caspases – a new target in inflammation and cancer therapy? Pol Merk Lek 2008, 139, 5–2 AUTOR?.
  8. Fan TJ, Han LH, Cong RS, Liang J: Caspase family proteases and apoptosis. Acta Biochim Biophys Sin 2005, 37, 719–727.
  9. Scorrano L, Korsmeyer SJ: Mechanisms of cytochrome c release by proapoptotic bcl-2 family members. Biochem Biophys Res Commun 2003, 304, 437–444.
  10. Wei MC, Zong WX, Cheng EHY, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ: Proapoptotic bax and bak: a requisite gateway to mitochondrial dysfunction and death. Science 2001, 292, 727–730.
  11. Sanges D, Comitato A, Tammaro R, Marigo V: Apoptosis in retinal degeneration involves cross-talk between apoptosis with inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Proc Natl Acad Sci USA 2006, 103, 17366–17371.
  12. Marigo V: Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration. Cell Cycle 2007, 6, 652–655.
  13. Bloodworth JM Jr: Diabetic retinopathy. Diabetes 1962, 11, 1–22.
  14. Dosso AA, Yenice-Ustun F, Sommerhalder J, Golay A, Morel Y, Leuenberger PM: Contrast sensitivity in obese dyslipidemic patients with insulin resistance. Arch Ophthalmol 1998, 116, 1316–1320.
  15. Ewing FM, Deary IJ, Strachan MW, Frier BM: Seeing beyond retinopathy in diabetes:electrophysiological and psychophysical abnormalities and alterations in vision. Endocr Rev 1998, 19, 462–476.
  16. Oshitari T, Yamamoto S, Hata N, Roy S: Mitochondriaand caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy. Br J Ophthalmol 2008, 92, 552–556.
  17. Khalfaoui T, Basora N, Ouertani-Meddeb A: Apoptotic factors (Bcl-2 and Bax) and diabetic retinopathy in type 2 diabetes. J Mol Hist 2010, 41, 143–152.
  18. Losiewicz MK, Fort PE: Diabetes impairs the neuroprotective properties of retinal alpha-crystallins. IOVS 2011, 52, 5034–5042.
  19. Leal EC, Aveleira CA, Castilho AF, Serra AM, Baptista FI, Hosoya K, Forrester JV, Ambrósio AF: High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway. Exp Eye Res 2009, 88, 983–991.
  20. Cordeiro MF, Migdal C, Bloom P, Fitzke FW, Moss SE: Imaging apoptosis in the eye. Eye 2011, 25, 545–553.
  21. Bringmann A, Wiedemann P: Muller glial cells in retinal disease. Ophthalmologica 2012, 227, 1–19.
  22. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK: The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 2005, 46, 2210–2218.
  23. Bui BV, Loeliger M, Thomas M, Vingrys AJ, Rees SM, Nguyen CT, He Z, Tolcos M: Investigating structural and biochemical correlates of ganglion cell dysfunction in streptozotocin-induced diabetic rats. Exp Eye Res 2009, 88, 1076–1083.
  24. van Dijk HW, Kok PHB, Garvin M: Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy. IOVS 2009, 50, 3404–3409.
  25. van Dijk HW, Verbraak FD, Kok PH: Decreased retinal ganglion cell layer thickness in patients with type 1 diabetes. IOVS 2010, 51, 3660–3666.
  26. Kowluru RA, Abbas SN: Diabetes-induced mitochondrial dysfunction in the retina. IOVS 2003, 44, 5327–5334.
  27. Abu El-Asrar AM, Dralands L, Missotten L, Al-Jadaan I, Geboes K: Expression of Apoptosis Markers in the Retinas of Human Subjects with Diabetes. IOVS 2004, 45, 2760–2766.
  28. Abu El-Asrar AM, Dralands L, Missotten L, Geboes K: Expression of antiapoptotic and proapoptotic molecules in diabetic retinas. Eye 2007, 21, 238–245.
  29. Orike N, Middleton G, Borthwick E, Buchman V, Cowen T, Davies AM: Role of PI3-Kinase, Akt and Bacl-2- related proteins in sustaining the survival of neurotrophic factorindependent adult sympathetic neurons. J Cell Biol 2001, 154, 995–1005.
  30. Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW: Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem 2001, 276, 32814–32821.
  31. Rickman DW, Nacke RF, Rickman CB: Characterization of the cell death promoter, Bad, in the developing rat retina and forebrain. Brain Res Dev Brain Res 1999, 115, 41–47.