Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 3, May-June, p. 463–467

doi: 10.17219/acem/43877

Publication type: original article

Language: English

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The Effects of Early Enteral Nutrition Products on the Healing of Colo-Colonic Anastomosis

Mustafa Sit1,A,B,D,F, Ahmet S. Ilgun2,B,C, Oguz Catal3,A,B, Ferda N. Koksoy4,C,E, Gülali Aktas5,E,F, Alper Cihan6,A,C

1 Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey

2 Department of General Surgery, Cayeli State Hospital, Rize, Turkey

3 Department of General Surgery, Ardahan State Hospital, Ardahan, Turkey

4 Department of General Surgery, Taksim Training and Education Hospital, Istanbul, Turkey

5 Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey

6 Department of General Surgery, Istanbul University, Istanbul, Turkey


Objectives. Complications after colorectal surgery have not been reduced in recent years. Anastomotic leakage is responsible for nearly all morbidity in colonic surgery and for about one third of the mortality.
Material and Methods. For the study, 34 albino Wistar rats (about 155–190 g in weight) were divided into four experimental groups. Each of the rats underwent an abdominal incision and resection of the colon 4 cm distal to the cecum to form a colo-colonic anastomosis. In the post-operative period, the first group (n = 8) were fed with standard rat food and water, the second group (n = 9) with dextrose + Ringer solution, the third group (n = 9) with Biosorb® (Nutricia, Zoetermeer, The Netherlands), and the fourth group (n = 8) with Impact® (Novartis Nutrition, USA).
Results. The blow-out pressure of the anastomoses was significantly different in the group fed 5% dextrose + + Ringer solution group than in the Biosorb® and Impact® groups.
Conclusion. None of the various nutrients investigated in the present study were significantly superior to standard foods in terms of the blow-out pressures. On the other hand, immunonutrients were more beneficial effects than other nutrients in terms of the healing of colonic anastomoses and post-operative weight loss.

Key words

anastomosis, nutrition, healing.

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