Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2015, vol. 24, nr 1, January-February, p. 167–172

doi: 10.17219/acem/38156

Publication type: review article

Language: English

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The Quality of Life and Psychological, Social and Cognitive Functioning of Patients with Acromegaly

Dorota Szcześniak1,B,D,F, Aleksandra Jawiarczyk-Przybyłowska2,E,F, Joanna Rymaszewska1,E,F

1 Division of Consulting Psychiatry and Neurobiological Research, Department of Psychiatry, Wroclaw Medical University, Poland

2 Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland


Acromegaly is a rare and chronic disease, most often caused by a pituitary adenoma. Excessive secretion of the growth hormone (GH) leads to hepatic secretion of insulin-like growth factor-1 (IGF-1), which in turn causes characteristic changes in the patient’s appearance, many skeletal deformities and metabolic disorders. In addition to somatic symptoms, acromegalic patients demonstrate psychosocial and personality deficits, as well as common co-occurrence of mental disorders. There are few studies investigating acromegaly in Poland. In recent years, the concept of quality of life has become fundamental to understanding health problems. Studies dealing with acromegaly likewise tend to include assessments of quality of life of patients suffering from this endocrinopathy.

Key words

acromegaly, GH, quality of life, mental disorder, cognitive disorder.

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