Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 5, September-October, p. 757–762

Publication type: original article

Language: English

The Prevalence of Allergic Diseases in Poland – the Results of the PMSEAD Study in Relation to Gender Differences

Jerzy Liebhart1,A,C,D,F, Rafał Dobek1,C,D, Józef Małolepszy1,A,E, Bogdan Wojtyniak2,A,C,D, Krzysztof Pisiewicz3,A,B, Tadeusz Płusa4,A, Urszula Gładysz5,B,C, The Pmsead Investigators,*,B

1 Department and Clinic of Internal Diseases, Geriatry and Allergology, Wroclaw Medical University, Poland

2 Department of Medical Statistics, National Institute of Hygiene, Warszawa, Poland

3 National Research Institute for Tuberculosis and Lung Diseases – Rabka Branch, Rabka-Zdrój, Poland

4 Department of Internal Medicine, Pneumonology and Allergology, Military Institute of Medicine, Warszawa, Poland



Background. Males and females exhibit different susceptibility to allergic diseases.
Objectives. The aim of the study was to evaluate gender-related differences in the prevalence of allergic diseases in Poland.
Material and Methods. To evaluate this problem, data from the Polish Multicenter Study of the Epidemiology of Allergic Diseases (PMSEAD) was analyzed. There were assessed 16,238 individuals, aged 3 to 80 years, among them 12,970 adults and 3,268 children.
Results. In adults the prevalence of asthma was 5.4%, seasonal allergic rhinitis 8.5%, persistent allergic rhinitis 3.0%, atopic dermatitis 1.6%, contact dermatitis 2.0%, and drug allergy 8.6%. In children asthma was diagnosed in 8.6% of the individuals assessed, seasonal allergic rhinitis in 8.6%, persistent allergic rhinitis in 2.1%, atopic dermatitis in 4.7%, contact dermatitis in 1.1% and drug allergy in 8.9%. Among the children in the sample, significantly higher prevalence rates were found in boys than in girls for asthma (10.9% vs. 6.3%; OR = 1.81; p < 0.001), seasonal allergic rhinitis (9.8% vs 7.4%; OR = 1.37, p = 0.018) and persistent allergic rhinitis (2.6% vs. 1.5%; OR = 1.74, p = 0.029). When comparing the differences by gender among adults, there was a lower proportion of male than female subjects suffering from asthma (4.9% vs. 5.8%; OR = 0.83, p = 0.018), seasonal allergic rhinitis (7.6% vs. 9.3%; OR = 0.81, p = 0.001), atopic dermatitis (1.1% vs. 2.0%; OR = 0.53, p < 0.001), contact dermatitis (1.1% vs. 2.8%; OR = 0.39; p < 0.001) and drug allergy (5.1% vs. 11.6%; OR = 0.41, p < 0.001).
Conclusion. The opposite susceptibility to allergic diseases among children and adults may indicate that sex hormones play an important role in this phenomenon.

Key words

allergic diseases, prevalence, gender differences.

References (24)

  1. Whitacre CC, Reingold SC, O’Looney PA: A gender gap in autoimmunity. Science 1999, 283, 1277–1278.
  2. Jensen-Jarolim E, Untersmayr E: Gender-medicine aspects in allergology. Allergy 2008, 63, 610–615.
  3. Murray CS, Canoy D, Buchan I, Woodcock A, Simpson A, Custovic A: Body mass index in young children and allergic disease: gender differences in a longitudinal study. Clin Exp Allergy 2011, 41, 78–85.
  4. Malling TH, Sigsgaard T, Andersen HR, Deguchi Y, Brandslund I, Skadhauge L, Thomsen G, Baelum J, Sherson D, Omland O: Differences in associations between markers of antioxidative defense and asthma are sex specific. Gend Med 2010, 7, 115–124.
  5. Bertelsen RJ, Instanes C, Granum B, Lødrup Carlsen KC, Hetland G, Carlsen KH, Mowinckel P, Løvik M: Gender differences in indoor allergen exposure and association with current rhinitis. Clin Exp Allergy 2010, 40, 1388–1397.
  6. Choi IS: Gender-specific asthma treatment. Allergy Asthma Immunol Res 2011, 3, 74–80.
  7. Liebhart J, Małolepszy J, Wojtyniak B, Pisiewicz K, Płusa T, Gładysz U: Polish Multicentre Study of Epidemiology of Allergic Diseases. Prevalence and risk factors for asthma in Poland: results from the PMSEAD study. J Investig Allergol Clin Immunol 2007, 17, 367–374.
  8. Central Statistical Office: Demographic Yearbook of Poland 1999, Warsaw 1999.
  9. Wieringa MH, Weyler JJ, Van Bever HP, Nelen VJ, Vermeire PA: Gender differences in respiratory, nasal and skin symptoms: 6–7 versus 13–14-year-old children. Acta Paediatr 1999, 88, 147–149.
  10. Shamssain MH, Shamsian N: Prevalence and severity of asthma, rhinitis, and atopic eczema in 13- to 14-year-old schoolchildren from the northeast of England. Ann Allergy Asthma Immunol 200, 86, 428–432.
  11. Shamssain MH, Shamsian N: Prevalence and severity of asthma, rhinitis, and atopic eczema: the north east study. Arch Dis Child 1999, 81, 313–317
  12. Osman M, Hansell AL, Simpson CR, Hollowell J, Helms PJ: Gender-specific presentations for asthma, allergic rhinitis and eczema in primary care. Prim Care Respir J 2007, 16, 28–35.
  13. Almqvist C, Worm M, Leynaert B: working group of GA2LEN WP 2.5 Gender. Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy 2008, 63, 47–57.
  14. Tollefsen E, Langhammer A, Romundstad P, Bjermer L, Johnsen R, Holmen TL: Female gender is associated with higher incidence and more stable respiratory symptoms during adolescence. Respir Med 2007, 101, 896–902.
  15. Samoliński B, Sybilski AJ, Raciborski F, Tomaszewska A, Samel-Kowalik P, Walkiewicz A, Lusawa A, Borowicz J, Gutowska-Slesik J, Trzpil L, Marszałkowska J. Jakubik N, Krzych E. Komorowski J, Lipiec A, Gotlib T, Samolińska-Zawisza U, Halat Z: Prevalence of rhinitis in Polish population according to the ECAP (Epidemiology of Allergic Disorders in Poland) study. Otolaryngol Pol 2009, 63, 324–330.
  16. Samoliński B, Sybilski A, Raciborski F, Tomaszewska A, Samel-Kowalik P, Walkiewicz A, Lusawa A, Borowicz J, Gutowska-Ślesik J, Trzpil L, Marszałkowska J, Jakubik N, Krzych E, Komorowski J, Lipiec A, Gotlib T, Samolińska-Zawisza U, Hałat Z, Dmochowska D, Kruczkowska G, Jakubowska K: Alergiczny nieżyt nosa w świetle badania ECAP. Alergia 2009, 2, 41–44.
  17. Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI: ISAAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 2009, 124, 1251-8.e23.
  18. Marinović-Kulisić S, Lipozencić J, Pastar Z: Contact allergy and sociodemographic characteristics. Coll Antropol 2006, 30, 273–278.
  19. Schäfer T, Böhler E, Ruhdorfer S, Weigl L, Wessner D, Filipiak B, Wichmann HE, Ring J: Epidemiology of contact allergy in adults. Allergy 2001, 56, 1192–1196.
  20. Samoliński B, Sybilski A, Raciborski F, Tomaszewska A, Samel-Kowalik P, Walkiewicz A, Lusawa A, Borowicz J, Gutowska-Ślesik J, Trzpil L, Marszałkowska J, Jakubik N, Krzych E, Komorowski J, Lipiec A, Gotlib T, Samolińska-Zawisza U, Hałat Z: Występowanie astmy oskrzelowej u dzieci, młodzieży i młodych dorosłych w Polsce w świetle badania ECAP. Alergia Astma Immunologia 2009, 14, 27–34.
  21. Zaitsu M, Narita S, Lambert KC, Grady JJ, Estes DM, Curran EM, Brooks EG,Watson CS, Goldblum RM, Midoro-Horiuti T: Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. Mol Immunol 2007, 44, 1977–1985.
  22. Narita S, Goldblum RM, Watson CS, Brooks EG, Estes DM, Curran EM, Midoro-Horiuti T: Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environ Health Perspect 2007, 115, 48–52.
  23. Ligeiro de Oliveira AP, Oliveira-Filho RM, da Silva ZL, Borelli P, Tavares de Lima W: Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone. Neuroimmunomodulation 2004, 11, 20–27.
  24. Chen W, Beck I, Schober W, Brockow K, Effner R, Buters JT, Behrendt H, Ring J: Human mast cells express androgen receptors but treatment with testosterone exerts no influence on IgE-independent mast cell degranulation elicited by neuromuscular blocking agents. Exp Dermatol 2010, 19, 302–304.