Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
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MNiSW – 40 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 3, May-June, p. 415–422

Publication type: original article

Language: English

Is There any Link Between Visceral Obesity and Adenovirus Infections in the Polish Population?

Iwona Bil-Lula1,A,C,D, Sylwia Stąpor2,B, Anna Krzywonos-Zawadzka1,B, Mieczysław Woźniak1,3,E,F

1 Department of Clinical Chemistry, Wroclaw Medical University, Poland

2 Laboratory of Haematological and Transplant Diagnostics, University Hospital No 1, Wroclaw, Poland

3 Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada


Background. Obesity is a chronic disease of multiple etiologies. Alongside the traditionally recognized causes of obesity, such as genetic inheritance and behaviour/environmental factors, in recent years adenoviral infections have been considered as a possible cause of obesity. Although numerous studies involving animals confirmed a strong relation between adenoviral infection and increased predisposition to obesity, an association of AdVs with human obesity has not been established conclusively.
Objectives. The main aim of this study was to establish an association between seroprevalence of adenoviruses and obesity in the Polish population.
Material and Methods. Eighty-six subjects (both obese and non-obese) participated in this study. The presence and the concentration of typically non-specific antibodies to human adenoviruses in serum were determined using ELISA immunoassay. A serum lipid-profile was evaluated using commercial tests.
Results. . A total of 89.5% of subjects were positive for AdV-IgG (n = 77); 10.5% (n = 9) were negative. In nonobese or lean AdV-IgG positive subjects, the parameters as: body weight (63.5 vs. 57.0, p = 0.02), WHR (0.77 vs. 0.73, p = 0.02) and waist circumference (74.5 vs. 69.0, p = 0.01) were significantly higher as AdV-IgG negative individuals.
Conclusion. We showed that there is an association between the presence of type unspecific anti-AdV antibodies in the serum and elevated body weight, BMI, WHR and waist circumference in lean and non-obese subjects from the Polish population.

Key words

adenoviruses, body mass index, waist-hip ratio, antibodies, obesity due to infection.

References (29)

  1. The challenge of obesity in the WHO European Region and the strategies for response. Branca F, Nikogosian H, Lobstein T, editors. World Health Organization 2007, Denmark, 323.
  2. Lee I, Shin H-J, Shin HJ, He J: Human adenovirus-36 antibody status is associated with obesity in children. Int J Pediatr Obes 2010, 5, 157–160.
  3. Ginnken V, Sitnykowsky L, Jeffery JE: Infectobesity: viral infections (especially with human adenovirus-36: Ad-36) may be a cause of obesity. Med Hypotheses 2009, 72, 383–388.
  4. Na HN, Hong YM, Kim J, Kim HK, Jo I, Nam JH: Association between human adenowirus-36 and lipid disorders in Korean schoolchildren. Int J Obes (Lond) 2010, 34, 89–93.
  5. Pasarica M, Mashtalir N, McAllister EJ, Kilroy GE, Koska J, Permana P, de Courten B, Yu M, Ravussin E, Gimble JM, Dhurandhar NV: Adipogenic human adenovirus Ad-36 induces commitent differentiation and lipid accumulation in human adipose-derived stem cells. Stem Cells 2008, 26, 969–978.
  6. Salehian B, Forman SJ, Kandeel FR, Bruner DE, He J, Atkinson RL: Adenovirus 36 DNA in adipose tissue of patient with unusual visceral obesity. Emerg Inf Dis 2010, 16, 850–852.
  7. Suplice HL, Bornschein A: Infections as the etiology for obesity. Arq Bras Endocrinol 2009, 53, 159–164.
  8. Vangipuram SD, Yu M, Tian J, Stanhope KL, Pasarica M, Havel PJ, Heydari AR, Dhurandhar NV: Adipogenic human adenovirus-36 reduces leptin expression and secretion and increases glucose uptake by fat cells. Int J Obes (Lond) 2007, 31, 87–96.
  9. Vangipuram SD, Sheele J, Atkinson RL, Holland TC, Dhurandhar NV: A human adenovirus enhances preadipocyte differentiation. Obes Res 2004, 12, 770–777.
  10. Cooper RJ, Hallett R, Tullo AB, Klapper PE: The epidemiology of adenovirus infection in Greater Manchester, UK 1982-96. Epidemiol Infect 2000, 125, 333–345.
  11. Horwitz MS: Adenoviruses. In: Fields Virology. Eds.: Knipe DM, Howley PM. Lippincott, Williams & Wilkins, Philadelphia 2001, 2301–2326.
  12. Atkinson RL: Viruses as an etiology of obesity. Mayo Clin Proc 2007, 82, 1192–1198.
  13. Dhurandhar NV, Augustus NV, Atkinson RL: Evidence of an association of a virus with obesity in humans. FASEB J 1997, 3, 230.
  14. Dhurandhar NV, Kulkarni PR, Ajinkya SM, Sherikar AA, Atkinson RL: Association of adenovirus infection with human obesity. Obes Res 1997, 5, 464–469.
  15. Schilham MW, Claas EC, van Zaane W, Heemskerk B, Vossen JM, Lankester AC, Toes RE, Echavarria M, Kroes AC, van Tol MJ: High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis 2002, 35, 526–532.
  16. Na HN, Kim J, Lee HS, Shim KW, Kimm H, Jee SH, Jo I, Nam JH: Association of human adenowirus-36 in overweight Korean adults. Int J Obes (Lond) 2011, Doi:10.1038/ijo.2011.102.
  17. Atkinson RL: Prevalence of infection with adenovirus-36 in Belgium and Holland and association with obesity. Obesity 2011, 19, 2.
  18. Van Ginneken V, Sitnyakowsky L, Jeffery JE: Infectoobesity: viral infections (especially with human adenovirus-36: Ad-36) may be cause of obesity. Med Hypotheses 2009, 72, 383–383.
  19. Goossens VJ, deJager SA, Grauls, GE: Lack of evidence for the role of human adenovirus-36 in obesity in a European cohort. Obesity 2011, 19, 220–221.
  20. Goossens VJ, Wolffs PF, Bruggeman CA: Response to prevalence of infection with adenovirus-36 in Belgium and Holland and association with obesity. Obesity 2011, 19, 3.
  21. The IDF consensus worldwide definition of the metabolic syndrome. International Diabetes Federation 2005, available on website:
  22. Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, Albu JB, Augustus AS: Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes 2005, 29, 281–286.
  23. Dhurandhar NV, Israel BA, Kolesar JM, Mayhew G, Cook ME, Atkinson RL: Transmissibility of adenovirusinduced adiposity in a chicken model. Int J Obes Relat Metab Disord 2001, 25, 990–996.
  24. Nwanegbo E, Vardas E, Gao W, Whittle H, Sun H, Rowe D, Robbins PD, Gambotto A: Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and The United States. Clin Diagn Lab Immun 2004, 11, 351–357.
  25. Ryan MAK, Gray GC, Malasig MD, Binn LN, Asher LV, Cute D, Kehl SC, Dunn BE, Yund AY: Two fatal cases of adenovirus related illness in previously healthy young adults – Illinois, 2000. Morb Mortal Wkly Rep 2001, 50, 553–555.
  26. So PW, Herlihy AH, Bell JD: Adiposity induced by adenovirus 5 inoculation. Int J Obes 2005, 29, 603–606.
  27. Dhurandhar NV, Kulkarni P, Ajinkya SM, Sherikar A: Effect of adenovirus infection on adiposity in chicken. Vet Microbiol 1992, 31, 101–107.
  28. Dhurandhar NV, Israel BA, Kolesar JM, Mayhew GF, Cook ME, Atkinson RL: Increased adiposity in animals due to a human irus. Int J Obes Relat Metab Disord 2000, 24, 989–996.
  29. Pasarica M, Shin AC, Yu M, Ou Yang HM, Rathod M, Jen KL, MohanKumar S, MohanKumar PS, Markward N, Dhurandhar NV: Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in rats. Obesity (Silver Spring) 2006, 14, 1905–1913.