Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1 (5-Year IF – 2.0)
Journal Citation Indicator (JCI) (2023) – 0.4
Scopus CiteScore – 3.7 (CiteScore Tracker 3.8)
Index Copernicus  – 171.00; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (EN)

Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 2, March-April, p. 169–175

Publication type: original article

Language: English

Interaction of Sertraline and Nimodipine on Some Behavioural Tests in Rats

Bilgin Kaygisiz1,B,D, Fikriye Yasemin Ozatik1,B, Kevser Erola1,C,E,F

1 Department of Pharmacology, Eskisehir Osmangazi University, Medical Faculty, Turkey

Abstract

Background. Intracellular calcium contributes to the development of affective disorders. also, calcium channel inhibitors influence the activity of many neurotransmitters and exert antidepressant and anxiolytic properties.
Objectives. The aim of this study was to examine the effects of sertraline on anxiety and depressive behaviors and the role of nimodipine, a calcium channel antagonist, on these effects.
Material and Methods. Forced swimming and elevated plus maze tests were used to assess depression and anxiety respectively in rats. Sertraline (10 mg/kg) was administered repeatedly for 7 days both alone and in combination with single (0.5 mg/kg) and repeated (0.5 mg/kg/7 days) nimodipine administrations.
Results. Both repeated sertraline (S) and its combination with single nimodipine administration (S + N) significantly decreased the immobility time compared to control. The combination of (S) with repeated doses of nimodipine (N/7d), significantly increased the immobility time compared to (S) and (S + N). Single dose of nimodipine (N) significantly increased the immobility time compared to (S) and (S + N), and decreased the number of divings compared to control. There was no significant difference between groups in terms of struggle and the time spent in closed arms of the elevated plus maze.
Conclusion. There was no interaction between a single dose of sertraline and nimodipine when administered in combination, while repeated nimodipine administration reversed the antidepressant-like effect of sertraline. We suggest that L-type calcium channels are involved in the antidepressant-like effect of sertraline. Neither single nor repeated nimodipine administration had a significant effect on both depressive behaviour and anxiety. We also propose that there is no interaction between the effects of sertraline and nimodipine on anxitey behavior.

Key words

sertraline, nimodipine, forced swimming test, elevated plus maze test.

References (30)

  1. Li H, Foss SM, Dobryy YL, Park CK, Hires SA, Shaner NC, Tsien RY, Osborne LC, Voglmaier SM: concurrent imaging of synaptic vesicle recycling and calcium dynamics. Front Mol Neurosci 2011, 4, 34.
  2. Giugovaz-Tropper B, González-Inchauspe C, Di Guilmi MN, Urbano FJ, Forsythe ID, Uchitel OD: P/Q-type calcium channel ablation in a mice glycinergic synapse mediated by multiple types of ca²+ channels alters transmitter release and short term plasticity. Neuroscience 2011, 192, 219–230.
  3. Scott VE, Vortherms TA, Niforatos W, Swensen AM, Neelands T, Milicic IBanfor PN, King A, Zhong C, Simler G, Zhan C, Bratcher N, Boyce-Rustay JM, Zhu CZ, Bhatia P, Doherty G, Mack H, Stewart AO, Jarvis MF: a-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats. Biochem Pharmacol 2012, 83, 406–418.
  4. Urbano FJ, Rosato-Siri MD, Uchitel OD: calcium channels involved in neurotransmitter release at adult, neonatal and P/Q-type deficient neuromuscular junctions (Review). Mol Membr Biol 2002, 19, 293–300.
  5. Galeotti N, Bartolini A, Ghelardini C: Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test. Neuropharmacology 2006, 50, 309–316.
  6. Busquet P, Nguyen NK, Schmid E, Tanimoto N, Seeliger MW, Ben-Yosef T, Mizuno F, Akopian A, Striessnig J, Singewald N: caV1.3 L-type ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype. Int J Neuropsychopharmacol 2010, 13, 499–513.
  7. El Ganouni S, Tazi A, Hakkou F: Potential serotonergic interactions with the anxiolytic-like effects of calcium channel antagonists. Pharmacol Biochem Behav 1998, 60, 365–369.
  8. Srivastava SK, Nath C: The differential effects of calcium channel blockers in the behavioural despair test in mice. Pharmacol Res 2000, 42, 293–297.
  9. Nowak G, Paul IA, Popik P, Young A, Skolnick P: ca2+ antagonists effect an antidepressant-like adaptation of the NMda receptor complex. Eur J Pharmacol 1993, 247, 101–102.
  10. Gaggi R, Dall’olio R: actions of nimodipine on the serotonergic systems of rat brain. Gen Pharmac 1997, 29, 415–419.
  11. Biala G, Budzynska B: Effects of acute and chronic nicotine on elevated plus maze in mice: involvement of calcium channels. Life Sci 2006, 79, 81–88.
  12. Shinnick-Gallagher P, McKernan MG, Xie J, Zinebi F: L-type voltage-gated calcium channels are involved in the in vivo and in vitro expression of fear conditioning. ann N Y acad Sci 2003, 985, 135–149.
  13. Nakazawa K, Inoue K, Ohara-Imaizumi M, Fujimori K, Takanaka A: Inhibition of ca-channels by diazepam compared with that by nicardipine in pheochromocytoma Pc12 cells. Brain Res 1991, 553, 44–50.
  14. Deák F, Lasztóczi B, Pacher P, Petheö GL, Valéria Kecskeméti, Spät A: Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells. Neuropharmacology 2000, 39, 1029–1036.
  15. Paul IA: antidepressant activity and calcium signaling cascades. Hum Psychopharmacol 2001, 16, 71–80.
  16. Pellow S, Chopin P, File SE, Briley M: Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985, 14, 149–167.
  17. Porsolt RD, Anton G, Blavet N, Jalfre M: Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978, 47, 379–391.
  18. Calin-Jageman I, Lee A: ca(v)1 L-type ca2+ channel signaling complexes in neurons. J Neurochem 2008, 105, 573–583.
  19. Green AR, DeSouza RJ, Davies EM, Cross AJ: The effects of ca2+ antagonists and hydralazine on central 5-hydroxytryptamine biochemistry and function in rats and mice. Br J Pharmacol 1990, 99, 41–46.
  20. Czyrak A, Mogilnicka E, Maj J: dihydropyridine calcium channel antagonists as antidepressant drugs in mice and rats. Neuropharmacology 1989, 28, 229–233.
  21. Aburawi S, Al-Tubuly R, Alghzewi E, Gorash Z: Effects of calcium channel blockers on antidepressant action of alprazolam and Imipramine. Libyan J Med 2007, 2, 169–175.
  22. Czyrak A, Mogilnicka E, Siwanowicz J, Maj J: Some behavioral effects of repeated administration of calcium channel antagonists. Pharmacol Biochem Behav 1990, 35, 557–560.
  23. Tazi A, Farh M, Hakkou F: Behavioral effects of a calcium channel antagonist: nifedipine. Fundam clin Pharmacol 1991, 5, 229–236.
  24. Biała G: antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice. Pol J Pharmacol 1998, 50, 117–124.
  25. Cohen C, Perrault G, Sanger DJ: assessment of the antidepressant-like effects of L-type voltage-dependent channel modulators. Behav Pharmacol 1997, 8, 629–638.
  26. Bagdy G, Graf M, Anheuer ZE, Modos EA, Kantor S: anxiety-like effects induced by acute fluoxetine, sertraline or m-cPP treatment are reversed by pretreatment with the 5-HT2c receptor antagonist SB-242084 but not the 5-HT1a receptor antagonist WaY-100635. Int J Neuropsychopharmacol 2001, 4, 399–408.
  27. To CT, Bagdy G: anxiogenic effect of central ccK administration is attenuated by chronic fluoxetine or ipsapirone treatment. Neuropharmacology 1999, 38, 279–282.
  28. Matsumoto Y, Kataoka Y, Watanabe Y, Miyazaki A, Taniyama K: antianxiety actions of ca++ channel antagonists with Vogel-type conflict test in rats. Eur J Pharmacol 1994, 264, 107–110.
  29. Viveros MP, Martín S, Ormazabal MJ, Alfaro MJ, Martín MI: Effects of nimodipine and nifedipine upon behavior and regional brain monoamines in the rat. Psychopharmacology (Berl) 1996, 127, 123–132.
  30. Urani A, Romieu P, Portales-Casamar E, Roman FJ, Maurice T: The antidepressant-like effect induced by the sigma(1) (sigma(1)) receptor agonist igmesine involves modulation of intracellular calcium mobilization. Psychopharmacology (Berl) 2002, 163, 26–35.
© Wroclaw Medical University