Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 5, September-October, p. 715–720

Publication type: original article

Language: English

Effectiveness and Safety of Topical Emollients in the Treatment of PUVA-Induced Pruritus

Skuteczność i bezpieczeństwo stosowania miejscowo emolientów w leczeniu świądu powstałego w wyniku zastosowania metody PUVA

Enver Turan1,A,B,C,D,F, Mehmet Salih Gurel2,E,F, Asli Turgut Erdemir2,A,B, Murat Usta3,C, Nurdan Seda Kutlu2,A,B, Nurdan Yurt2,B,E

1 Harran University, Faculty of Medicine, Department of Dermatology, Sanliurfa, Turkey

2 Istanbul Educational and Research Hospital, Department of Dermatology, Istanbul, Turkey

3 Giresun University Faculty of Medicine, Department of Biochemistry, Giresun, Turkey


Background. In this study we tried to assess the efficacy of topical emollients in the treatment of patients with PUVA-induced pruritus.
Material and Methods. 41 patients over 18 years of age, who received PUVA treatment in the phototherapy unit, were included in the study. Patients were randomly divided into two groups; Group I was administered with a 4% urea lotion and Group II was administered with liquid petrolatum. The follow-up period was minimum 4 weeks. During the first 2 weeks, patients were administered topical emollients and received PUVA treatment together. The next 2 weeks, they continued PUVA treatment without any medication.
Results. When time-dependent changes in the visual analogue scale scores for pruritus of both groups were considered, both treatment methods were found to be remarkably successful (p < 0.0001). In addition, an insignificant group-time interaction was identified (p = 0.753).
Conclusion. Topical emollients were found to be effective in the treatment of PUVA-induced pruritus. Both forms of medication can be successfully administered and increase the patient’s compliance with medication.

Key words

emollients, pruritus, PUVA therapy, visual analogue scale, Likert scale.

Słowa kluczowe

emolienty, świąd, leczenie PUVA, wizualna skala analogowa, skala Likerta.

References (18)

  1. Amirnia M, Khodaeiani E, Fouladi RF, Hashemi A: Topical steroids versus PUVA therapy in moderate plaque psoriasis: A clinical trial along with cost analysis. J Dermatolog Treat 2011.
  2. Rama Sastry CV, Kar PK: A study of psoralen photochemotherapy with topical tar in the management of psoriasis vulgaris. Indian J Dermatol Venereol Leprol 2001, 67, 305–308.
  3. Pozo-Roman T, Gonzalez-Lopez A, Velasco-Vaquero ME, Nunez-Cabezon M: Psoralen cream plus ultraviolet A photochemotherapy (PUVA cream): our experience. J Eur Acad Dermatol Venereol 2006, 20, 136–142.
  4. Abdullah AN, Keczkes K: Cutaneous and ocular side-effects of PUVA photochemotherapy – a 10-year follow-up study. Clin Exp Dermatol 1989, 14, 421–424.
  5. Wolff K: Side-effects of psoralen photochemotherapy (PUVA). Br J Dermatol 1990, 122, 117–125.
  6. Melski JW, Tanenbaum L, Parrish JA, Fitzpatrick TB, Bleich HL: oral methoxsalen photochemotherapy for the treatment of psoriasis: a cooperative clinical trial. 1977. J Invest Dermatol 1989, 92, 153S, discussion 154S–156S.
  7. Rogers S, Marks J, Shuster S: Itch following photochemotherapy for psoriasis. Acta Derm Venereol 1981, 61, 178–180.
  8. Roelandts R, Stevens A: PUVA-induced itching and skin pain. Photodermatol Photoimmunol Photomed 1990, 7, 141–142.
  9. Jordan WP: PUVA, pruritus, and the loss of the axon flare. Arch Dermatol 1979, 115, 636.
  10. Wewers ME, Lowe NK: A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health 1990, 13, 227–236.
  11. Laube S, George SA: Adverse effects with PUVA and UVB phototherapy. J Dermatolog Treat 2001, 12, 101–105.
  12. Henseler T, Wolff K, Honigsmann H, Christophers E: oral 8-methoxypsoralen photochemotherapy of psoriasis. The European PUVA study: a cooperative study among 18 European centres. Lancet 1981, 1, 853–857.
  13. Burrows NP, Norris PG: Treatment of PUVA-induced skin pain with capsaicin. Br J Dermatol 1994, 131, 584–585.
  14. Loden M: Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 2003, 4, 771–788.
  15. du Toit R, Pritchard N, Heffernan S, Simpson T, Fonn D: A comparison of three different scales for rating contact lens handling. optom Vis Sci 2002, 79, 313–320.
  16. Grant S, Aitchison T, Henderson E, Christie J, Zare S, McMurray J, Dargie H: A comparison of the reproducibility and the sensitivity to change of visual analogue scales, Borg scales, and Likert scales in normal subjects during submaximal exercise. Chest 1999, 116, 1208–1217.
  17. Johansson O: „PUVA-induced skin pain” – speculations from a neuroscientist. Exp Dermatol 1994, 3, 95–96.
  18. Yosipovitch G: Dry skin and impairment of barrier function associated with itch – new insights. Int J Cosmet Sci 2004, 26, 1–7.