Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 5, September-October, p. 655–658

Publication type: original article

Language: English

Levels of Insulin, IL-6 and CRP in Patients with Unstable Angina

Stężenie insuliny, IL-6 i CRP u pacjentów chorych na niestabilną dławicą piersiową

Isam Hussain T. Al-Karkhi1,A,C,D,E,F, Ammal Esmaeel Ibrahim2,A,B,C,D, Abeer Khalid Yaseen3,B,C,E

1 College of Dentistry, University of Baghdad, Bab Al Mozam, Baghdad, Iraq

2 Chemistry Department, Collage of Science Al-Nahrain University, Al-Jadrya, Baghdad, Iraq


Background. Unstable angina is a condition in which your heart doesn’t get enough blood flow and oxygen. It may lead to a heart attack. Insulin resistance is typically defined as decreased sensitivity or responsiveness to metabolic actions of insulin, such as insulin-mediated glucose disposal in skeletal muscle and adipose tissue and inhibition of hepatic glucose production. Crosstalk between inflammatory signaling pathways and insulin signaling pathways causes metabolic insulin resistance and endothelial dysfunction.
Objectives. The present study aimed to evaluate the serum levels of pro-inflammatory cytokines and insulin in unstable angina patients.
Material and Methods. The study included 50 patients with unstable angina divided into a female group which contained 16 female patients with an age range of 35–73 years, and a male group which contained 34 male patients with an age range of 40–72 years. Control groups contained forty healthy individuals divided into a female group which contained 16 healthy females with an age range of 35–73 years, and a male group which contained 24 males with an age range of 42–72 years. ELISA kits were used to measure insulin, IL-6 and CRP. The kits were imported from Biological Company in the United States of America.
Results. The levels of insulin and IL-6 were considerably elevated throughout (p < 0.001), an optimistic relationship concerning insulin with CRP and IL-6 in unstable angina patients.
Conclusion. There was increase in the level of insulin regarding patients with unsteady angina as a result of insulin resistance that was caused by the elevated level of proinflammatory cytokine (IL-6).

Key words

insulin, CRP, IL-6, unstable angina.

Słowa kluczowe

insulina, CRP, IL-6, niestabilna dławica piersiowa.

References (13)

  1. Abawi M, Khatibi S, Boersma E, Deckers JW: The Effectiveness of Percutaneous Coronary Intervention plus optimal Medical Therapy versus optimal Medical Therapy alone in Stable Coronary Artery Disease. A systematic Review. Erasmus J Med 2011, 1, 32–43.
  2. Kansagara D, Rongwei, Freeman M, Wolf F, Helfand M: Intensive Insulin Therapy in Hospitalized Patients: A Systematic Review. Ann Intern Med 2011, 154, 268–282.
  3. Kim J, Montagnani M, Koh KK, Quon MJ: Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006, 113, 1888–1904.
  4. Petersen KF, Dufour S, Savage DB, Bilz S: The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA 2007, 104, 12587–12594.
  5. Khaled M, Mahfouz M: Curcumin Improves Insulin Sensitivity and Ameliorates Serum Pro-inflammatory Cytokines Levels in Diabetes Rat model Irrespective of type of Diabetes. J Am Sci 2011, 7, 794–799.
  6. Pedersen BK: Enhancing influence of intranasal IL-6 on slow-wave activity and memory consolidation during sleep. Federation of American Societies for Experimental Biology 2009, 23, 3629–3636.
  7. Pepys MB, Hirschfield GM: C-reactive protein: a critical update. J Clin Invest 2003, 111, 1805–1812.
  8. Cleland SJ, Petrie JR, Ueda S, Elliott HL and John MC: Insulin-Mediated Vasodilation and glucose Uptake Are Functionally Linked in Humans. Hypertension 1999, 33, 554–558.
  9. Ogata A, Morishima A, Hirano T, Hishitani Y, Hagihara K, Shima Y, Narazaki M, Tanaka T: Improvement of HbA1c during treatment with humanized anti-interleukin 6 receptor antibody, tocilizumab. Ann Rheum Dis June 2011, 70, 1164–1165.
  10. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G: Adipose tissue tumor necrosis factor and inter-leukin-6 expression in human obesity and insulin resistance. Am J Physiol 2001, 280, E745–E751.
  11. Reyes M, Gahagan S, Diaz E, Blanco E, Leiva L, Lera L, Burrows R: Relationship of Adiposity and Insulin Resistance Mediated by Inflammation in a group of overweight and obese Chilean Adolescents. Nutrition J 2011, 10, 4, 1–3.
  12. Khan R, Haque SF, Quaiser S: The inflammatory markers: C-Reactive Protein and TNF-α predict Cardiovascular risks in obese North Indian subjects. Biomedical Research 2011, 22, 475–480.
  13. Valiollah S, Mojtaba E, Vahid I, Ali SM: Association of C Reactive Protein with Insulin Resistance in Type 2 Diabetes. IPCBEE 2011, 5, 407–409.