Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2013, vol. 22, nr 4, July-August, p. 481–487

Publication type: original article

Language: English

Comparison of Topical Sucralfate and Silver Sulfadiazine Cream in Second Degree Burns in Rats

Porównanie skuteczności miejscowego sukralfatu i soli srebrowej sulfadiazyny w kremie w leczeniu oparzeń drugiego stopnia u szczurów

Akram Beheshti1,A,B,E, Younes Shafigh1,B,E, Amir-abdollah Zangivand1,C,D,E,F, Fatemeh Samiee-Rad1,C,D,E,F, Gholamreza Hassanzadeh1,B,C, Navid Shafigh1,B,G

1 Qazvin University of Medical Sciences, Iran

Streszczenie

Wprowadzenie.Najbardziej rozpowszechnionym sposobem miejscowego leczenia oparzeń II stopnia jest sól srebrowa sulfadiazyny 1% (SSD). Ostatnie badania wykazały, że leczenie oparzeń II stopnia jest opóźnione z wykorzystaniem SSD. Jednym z możliwych opatrunków oparzeniowych jest sukralfat.
Cel pracy. Analiza porównawcza wpływu sukralfatu i SSD na oparzenia drugiego stopnia u szczurów.
Materiał i metody. Czterdzieści osiem samców szczurów podzielono na trzy równe grupy. Model oparzenia utworzono na grzbiecie wszystkich szczurów. Spalone obszary w grupach pierwszej, drugiej i trzeciej codziennie pokrywano odpowiednio sukralfatem, SSD i zimną śmietaną (grupa kontrolna). Na koniec dnia 7, 14, 21 i 28 szczury usypiano i spalone próbki tkanki skóry zebrano do badań histopatologicznych.
Wyniki. Na koniec badania naskórek i warstwa rogowa skóry były całkowicie uformowane w grupie SSD i sukralfatu, jednak skóra właściwa została wytworzona w grupie z sukralfatem. Skuteczność gojenia ran obliczono na 76%, 91% i 100% w grupie kontrolnej, z solą srebrową sulfadiazyny i z sukralfatem.
Wnioski. Sukralfat wywiera korzystny wpływ na gojenie ran. Przy zastosowaniu miejscowym sukralfat przyspieszał proces gojenia ran po oparzeniu w porównaniu z grupą kontrolną i SSD oraz może być stosowany jako alternatywa lub środek wspomagający leczenie w przyszłości.

Key words

sucralfate, silver sulfadiazine, second degree burns, rat.

Słowa kluczowe

sukralfat, sól srebrowa sulfadiazyny, drugi stopień oparzenia, szczur.

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