Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2012, vol. 21, nr 2, March-April, p. 235–244

Publication type: review article

Language: English

The Role of Human Papillomavirus in the Malignant Transformation of Cervix Epithelial Cells and the Importance of Vaccination Against This Virus

Rola HPV w mechanizmie transformacji nowotworowej komórek nabłonka szyjki macicy oraz znaczenie szczepionki przeciwko temu wirusowi

Urszula Ciesielska1,, Katarzyna Nowińska1,, Marzena Podhorska-Okołów1,, Piotr Dzięgiel1,

1 Department of Histology and Embryology, Wroclaw Medical University

Abstract

Human papillomavirus (HPV) belongs to the diverse group of sexually transmitted viruses that manifest affinity to the squamous epithelia of the skin and mucous membranes. Over 100 types of HPV have been described and identified in human tissues, and it has been proved that persistent infection with high-risk types of the virus (types 16 and 18 in particular) could lead to cervical cancer. High-risk HPV types have been found in approximately 70% of all cases of cervical cancer worldwide. The aim of this study was to describe the role of HPV in the process of neoplastic transformation in epithelial cells and to emphasize the prophylactic significance of vaccinations against the virus.

Streszczenie

Wirus brodawczaka ludzkiego (HPV – human papillomavirus) jest zaliczany do zróżnicowanej grupy wirusów przenoszonych drogą płciową, wykazujących powinowactwo do nabłonka wielowarstwowego płaskiego skóry oraz błon śluzowych człowieka. Do chwili obecnej wyodrębniono ponad 100 typów tego wirusa i udowodniono, iż przetrwałe zakażenie jego onkogennymi typami (zwłaszcza 16 i 18) może prowadzić do rozwoju raka szyjki macicy. Obecność tych typów HPV stwierdzono w około 70% przypadków raka szyjki macicy na świecie. Celem pracy było omówienie roli HPV w procesie transformacji nowotworowej komórek nabłonkowych oraz podkreślenie znaczenia profilaktycznego zastosowania szczepionki przeciw temu wirusowi.

Key words

human papillomavirus (HPV), neoplastic transformation, cancer of uterine cervix, vaccine against HPV

Słowa kluczowe

wirus brodawczaka ludzkiego (HPV), transformacja nowotworowa, rak szyjki macicy, szczepionka przeciw HPV

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