Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2011, vol. 20, nr 4, July-August, p. 407–411

Publication type: editorial article

Language: English

Reflux Disease – Historical Overview

Choroba refluksowa – spojrzenie historyczne

Marta Strutyńska-Karpińska1,

1 Department and Clinic of Gastrointestinal and General Surgery, Wroclaw Medical University, Wroclaw, Poland


The review presents the development and successive changes in the opinion on the essence of reflux disease which took place over the last century. Major milestones increasing our knowledge on the pathogenesis, diagnostics and treatments of this disease were reviewed on the basis of available literature. Special attention has been paid to the role of surgery in treatment of the disease, which is currently considered the most common dysfunction of the alimentary tract.


W pracy przedstawiono rozwój i kolejne zmiany poglądów, dotyczących istoty choroby refluksowej, które dokonały się w ciągu wieku. Na podstawie dostępnego piśmiennictwa prześledzono najważniejsze punkty zwrotne poszerzające wiedzę na temat patogenezy, diagnostyki oraz sposobów leczenia tej jednostki chorobowej. Zwrócono uwagę na rolę chirurgii w leczeniu choroby uznanej obecnie za najczęstsze zaburzenia czynności przewodu pokarmowego.

Key words

gastroesophageal reflux disease

Słowa kluczowe

choroba refluksowa

References (44)

  1. Cannon WB: Conditions affecting the activities of cardia. In: The mechanical factors of digestion. Ed. Arnold E, New York, Longmans, Green, and Co., 1911, 32–44.
  2. Tileston W: Peptic ulcer of the oesophagus. Am J Med Sci 1906, 132, 240–265.
  3. Winkelstein A: Peptic esophagitis (a new clinical entity). Jama 2935, 185, 906–909.
  4. Bernstein LM, Baker LA: A clinical test for esophagitis. Gastroenterology 1958, 34(8), 760–781.
  5. Allison PR: Peptic ulcer of the esophagus. J Thorac Surg 1946, 15, 308–317.
  6. Allison PR: Reflux esophagitis, sliding hiatal hernia, and the anatomy of repair. Surg Gynecol Obstet 1951, 92, 419–431.
  7. Palmer ED: The hiatus hernia – esophagitis – esophageal stricture complex. Twenty-year prospective study. Am J Med 1968, 44, 566–579.
  8. Code CF, Creamer B, Schegel JF, Olsen AM, Donoghue FE: An atlas of esophageal motility in health and disease. Springfield, IL: Charles C. Thomas, 1958.
  9. Tuttle SG, Grossman MI: Detection of gastroesophageal regurgitation by simultaneous measurement of intraluminal pressure and pH. Proc Soc Exp Biol Med 1958, 98, 225–227.
  10. Dodds WJ: Instrumentation and methods for intraluminal esophageal manometry. Arch Intern Med 1976, 136, 515–523.
  11. Johnson LF, DeMeester TR: Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol 1974, 62, 325–332.
  12. Hirschowitz BI: Endoscopic examination of the stomach and duodenal cap with fiberoscope. Lancet 1961, 1, 1074–1078.
  13. Savary M, Miller G: The Oesophagus. Handbook and atlas of endoscopy. Solothorn, Switzerland, Gassman AG, 1978.
  14. Lundell LR, Dent J, Benetti JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L: Endoscopic assesment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999, 45, 172–180.
  15. Barrett NR: Chronic peptic ulcer of the oesophagus and “oesophagitis”. Br J Surg 1950, 38, 175–182.
  16. Paull A, Trier JS, Dalton MD, Camp RC, Loeb P, Goyal RK: The histologic spectrum of Barrett’s esophagus. N Engl J Med 1976, 295, 476–480.
  17. Spechler SJ, Goyal RK: The columnar lined esophagus, intestinal metaplasia, and Norman Barrett. Gastroenterology 1996, 110, 614–621.
  18. Schilling D, Spiethoff A, Rosenbaum A, Hartmann D, Eickhoff A, Jakobs R, Weickert U, Rebe M, Bohrer MH, Riemann JF: Does Cytokeratin 7/20 immunoreactivity help to distinguish Barrett’s esophagus from gastric intestinal metaplasia? Results of a prospective study of 75 patients. Pathol Res Pract 2005, 200, 801–805.
  19. Colleypriest BJ, Farrant JM, Slack JM, Tosh D: The role of Cdx2 in Barrett’s metaplasia. Biochem Soc Trans 2010, 38, 364–369.
  20. Falk GW: Radiofrequency ablation of Barrett’s esophagus: let’s not get ahead of ourselves. Dig Dis Sci 2010, 55, 1811–1814.
  21. Bisschops R: Optimal endoluminal treatment of Barrett’s esophagus: integrating novel strategies into clinical practice. Expert Rev Gastroenterol Hepatol 2010, 4, 319–333.
  22. Dent J, Holloway RH, Tooli J, Dodds WJ: Mechanisms of lower oesophageal sphincter incompetence in patients with symptomatic gastrooesophageal reflux. Gut 1988, 29, 1020–1028.
  23. Sifrim D, Holloway R: Transient lower esophageal sphincter relaxations: how many or how harmful? Am J Gastroenterol 2001, 96, 2529–2532.
  24. Liakakos T, Karamanolis G, Patapis P, Misiakos EP: Gastroesophageal reflux disease: medical or surgical treatment. Gastroenterol Res Pract 2009, 2009, 371580, doi: 10.1155/2009/371580.
  25. Pandolfino JE, Richter JE, Ours T, Guardino JM, Chapman J, Kahrilas PJ: Ambulatory esophageal pH monitoring using a wireless system. Am J Gastroenterol 2003, 98, 740–749.
  26. Sifrim D, Castell D, Dent J, Kahrilas PJ: Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004, 53, 1024–1031.
  27. Błoński W, Hila A, Castel DO: Rola wielokanałowej śródściennej impedancji w ocenie czynności przełyku i refluksu żołądkowo-przełykowego. Gastroenterol Pol 2006, 13, 429–435.
  28. Nissen R: A simple operation for control of reflux esophagitis. Schweiz Med Wochenschr 1956, 86, 590–592.
  29. Lord RV, DeMester SR, Peters Jh, Hagen JA, Elyssnia D, Sheth CT, DeMester TR: Hiatal hernia, lower esophageal sphincter incompetence, and effectiveness of Nissen fundoplication in the spectrum of gastroesophageal reflux disease. J Gastrointest Surg 2009, 13, 602–610.
  30. Stylopoulos N, Rattner DW: The history of hiatal hernia surgery: from Bowdich to laparoscopy. Ann Surg 2005, 241, 185–193.
  31. Strutyńska-Karpińska M, Budrewicz-Czapska K, Czapla L, Nienartowicz M, Szelachowski P, Grabowski K: Complicated gastroesophageal reflux disease – therapeutic dilemmas. Adv Clin Exp Med 2010, 19, 361–367.
  32. Chen D, Barber C, McLoughlin P, Thavaneswaran P, Jamieson GG, Maddern GJ: Systematic review of endoscopic treatments for gastro-oesophageal reflux disease. Br J Surg 2009, 96(2), 128–136.
  33. Dundon JM, Davis SS, Hazey JW et al.: Radiofrequency energy delivery to the lower esophageal sphincter (Stretta procedure) does not prove long term symptom control. Surg Innov 2008, 15, 4, 297–301.
  34. Robertson DA, Aldersley MA, Shepherd H, Lloyd RS, Smith CL: H2 antagonists in the treatment of reflux oesophagitis: can physiological studies predict the response? Gut 1987, 28, 946–949.
  35. Lowe RC, Wolfe MM: The pharmacological management of gastroesophageal reflux disease. Minerva Gastroenterol Diabetol 2004, 50, 227–237.
  36. Fass R, Shapiro M, Dekel R, Sewell J: Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease – where next? Aliment Pharmacol Ther 2005, 22, 79–94.
  37. Zerbib F, Duriez A, Roman S, Capdepont M, Mion F: Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors. Gut 2008, 57, 157–160.
  38. Pisegna J, Holtmann G, Howden CW, Katelaris PH, Sharma P, Spechler S, Triadafilopoulos G, Tytgat G: Review article: oesophageal complications and consequenses of persistent gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2004, suppl 9, 47–56.
  39. Frazzoni M, Manno M, De Micheli E, Savarino V: Pathophysiological characteristics of various forms of gastrooesophageal reflux disease. Spectrum disease or distinct phenotypic presentations? Dig Liver Dis 2006, 38, 643–648.
  40. Polese L, Angriman I, Bonello E, Erroi F, Scarpa M, Frego M, D’Amico DF, Norberto L: Endoscopic dilation of benign esophageal strictures in surgical unit: a report on 95 cases. Surg Laparosc Endosc Percutan Tech 2007, 17, 477–481.
  41. Randjelovic T, Dikic S, Filipovic B, Gacic D, Bilanovic D, Stanisavlijevic N: Short-segment jejunoplasty: the option treatment in management of benign esophageal stricture. Dis Esophagus 2007, 20, 239–246.
  42. Siersema PD: Stenting for benign esophageal strictures. Endoscopy 2009, 41, 363–373.
  43. Weldon DR: Gastroesophageal reflux disease and sinusitis: their role in patients with chronic cough. Allergy Asthma Proc 2006, 27, 36–44.
  44. Vakil N, Zanten SV, Kahrilas P, Dent J, Jones R: Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006, 101, 1900–1920.