Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2011, vol. 20, nr 1, January-February, p. 5–14

Publication type: editorial article

Language: English

Morphogenetic and Clinical Perspectives on the Neogenesis of Pancreatic Duct Ligation-Induced Islet Cells – a Review

Morfogenetyczne i kliniczne perspektywy neogenezy komórek wysp Lagerhansa wywołanej przez podwiązanie przewodu trzustkowego

Venant Tchokonte-Nana1,2,, Benjamin Longo-Mbenza1,, Benedict J. Page2,, Donald F. du Toit2,

1 Walter Sisulu University, School of Medicine, Mthatha, RSA

2 Stellenbosch University, Faculty of Health Sciences, Bellville, RSA

Abstract

This review focuses on recent progress in understanding morphogenetic findings on the neogenesis of islet beta cells following Pancreatic Duct Ligation (PDL) in animal models. These results may give hope for modifications in the treatment of diabetes in general and transplantation in particular. On the basis of this review, translational studies should be developed to allow information on beta-cell neogenesis to be integrated into a potential therapy for Diabetes Mellitus (DM) in humans. Further studies on the development of animal models that will produce PDL islets for transplantation are urgently needed.

Streszczenie

Praca poglądowa skupia się się na obecnym postępie w rozumieniu zmian w neogenezie komórek beta wysp Lagerhansa w następstwie podwiązania przewodu trzustkowego (PDL – pancreatic duct ligation) na modelu zwierzęcym. Uzyskane wyniki pozwalają mieć nadzieję na zmianę zasadniczego leczenia cukrzycy w przyszłości, a zwłaszcza zastosowanie leczenia za pomocą transplantacji. Na podstawie niniejszej pracy poglądowej można stwierdzić, że powinny zostać prowadzone badania, aby pogłębić wiedzę dotyczącą neogenezy komórek beta w możliwej terapii cukrzycy u ludzi. Konieczne są pilne badania na modelu zwierzęcym w celu uzyskania wysp do przeszczepów.

Key words

pancreatic duct ligation, beta cells, neogenesis, islet, gene expression, diabetes mellitus

Słowa kluczowe

podwiązanie przewodu trzustkowego, komórki beta, neogeneza, wyspa, ekspresja genu, cukrzyca

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