Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2010, vol. 19, nr 3, May-June, p. 379–387

Publication type: review article

Language: English

The Role of Thrombin-Activatable Fibrinolysis Inhibitor in the Pathophysiology of Hemostasis

Rola inhibitora fibrynolizy aktywowanego trombiną w patofizjologii hemostazy

Joanna Dubis1,, Wojciech Witkiewicz1,

1 Regional Specialist Hospital in Wrocław, Research and Development Center, Poland

Abstract

The fibrinolytic system is responsible for the enzymatic degradation of fibrin and participates in a wide variety of physiological and pathological processes, such as hemostatic balance, tumor invasion, angiogenesis, tissue remodeling, and reproduction. The balance between clot formation and fibrinolysis is controlled by the molecular components of the hemostatic system, including thrombin-activatable fibrinolysis inhibitor (TAFI). Several studies indicate an important role for plasma TAFI in the regulation of fibrinolysis. It is activated by thrombin during blood clotting and is a link between coagulation and fibrinolysis. Moreover, TAFI plays a pivotal role in inflammation. In this review, recent basic and clinical findings that demonstrate the role of TAFI in regulating the crosstalk between coagulation, fibrinolysis, and inflammation are summarized.

Streszczenie

Układ fibrynolizy jest odpowiedzialny za enzymatyczną degradację fibryny, a także uczestniczy w wielu procesach fizjologicznych i patologicznych, takich jak: hemostaza, migracja komórek nowotworowych, angiogeneza, przebudowa tkanek, rozród. Równowaga między procesem powstawania skrzepu a fibrynolizą jest precyzyjnie kontrolowana przez czynniki układu hemostazy, w tym przez inhibitor fibrynolizy aktywowany trombiną (TAFI). Wykazano, że osoczowe stężenie TAFI ma znaczący wpływ na proces fibrynolizy w stanach patologicznych. Inhibitor TAFI jest aktywowany przez trombinę i jest czynnikiem wiążącym między procesem koagulacyjnym a fibrynolizą. TAFI pełni także ważną rolę w procesie zapalenia. W pracy przedstawiono najnowsze wyniki badań podstawowych i klinicznych na temat roli TAFI w regulacji powiązań między procesami krzepnięcia krwi, fibrynolizy i zapalenia.

Key words

thrombin-activatable fibrinolysis inhibitor, hemostasis

Słowa kluczowe

inhibitor fibrynolizy aktywowany trombiną, hemostaza

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