Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2010, vol. 19, nr 3, May-June, p. 337–345

Publication type: original article

Language: English

Zinc, Cooper, Manganese, and Selenium Status in Pre- and Postmenopausal Women During Sex Hormone Therapy

Stężenia cynku, miedzi, manganu i selenu u kobiet menopauzalnych przyjmujących terapię hormonalną

Grażyna Bednarek-Tupikowska1,, Anna Jodkowska2,, Jolanta Antonowicz-Juchniewicz2,

1 Department of Endocrinology, Diabetology, and Isotope Treatment, Wroclaw Medical University, Poland

2 Department of Internal Medicine, Occupational Diseases, and Hypertension, Wroclaw Medical University, Poland


Background. The impact of estrogen deficiency after menopause on trace minerals has not been widely studied.
Objectives. The aim of this study was to compare trace mineral levels of postmenopausal women with those of premenopausal women of similar age and to determine the impact of estrogen (ET) and estro-progestin (HT) therapy on them.
Material and Methods. E2, FSH, Cu, Zn, Se, and Mn concentrations in serum and/or whole blood in 80 postmenopausal women (M1 group: 26 with surgically induced and 54 with physiological menopause) and in 40 premenopausal controls (C) were determined. In the M1 group the measurements were repeated after 4 months of ET or HT.
Results. The study showed that trace mineral status in the postmenopausal women was slightly different from that of the C. The serum Zn level after menopause was considerably higher than that of the C and tended to decrease after ET, whereas it remained unchanged after HT. Serum Mn level after menopause was similar to that of the controls, but it decreased significantly after ET, whereas it remained unchanged after HT. The rest of the trace element concentrations showed only slight changes.
Conclusion. The precise impact of estrogen deficiency after menopause and hormonal therapy on trace mineral status needs further large-population studies.


Wprowadzenie. Wpływ niedoboru estrogenów na stężenia metali śladowych u kobiet po menopauzie nie został dotychczas dobrze poznany.
Cel pracy. Zbadano, czy stężenia Zn, Cu, Se i Mn w surowicy i krwi pełnej kobiet przed i po menopauzie różnią się oraz oceniono wpływ terapii estrogenowej (ET) i estroprogestagenowej (HT) na stężenia tych metali.
Materiał i metody. Porównano 80 zdrowych kobiet po menopauzie (54 – naturalnej, 26 – chirurgicznej) i 40 przed menopauzą (K). Oznaczano stężenia E2, FSH w surowicy oraz Zn, Cu, Se i Mn w surowicy i krwi pełnej, przed i po 4-miesięcznej terapii: u kobiet z zachowaną macicą – HT, u kobiet z menopauzą chirurgiczną – ET.
Wyniki. Wykazano, że stężenia metali śladowych u kobiet po menopauzie nieznacznie różnią się od stężeń obserwowanych w grupie kontrolnej. Stężenie cynku w surowicy było większe u kobiet po menopauzie niż w grupie kontrolnej i pod wpływem terapii estroprogestagenowej (HT) nieznacznie zmniejszało się, pozostając bez zmian pod wpływem terapii estrogenowej (ET). Wyjściowo porównywalne między badanymi grupami stężenie manganu w surowicy istotnie zmniejszyło się pod wpływem ET i pozostało niezmienione pod wpływem HT. Stężenia pozostałych badanych mikroelementów zmieniały się jedynie w nieistotnym zakresie.
Wnioski. Dokładne określenie wpływu niedoboru estrogenów na stężenia metali śladowych u kobiet po menopauzie i znaczenia terapii hormonalnej w tym aspekcie wymaga przeprowadzenia dalszych badań na większej populacji.

Key words

copper, zinc, selenium, manganese, menopause, hormonal therapy

Słowa kluczowe

miedź, cynk, selen, mangan, menopauza, terapia hormonalna

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