Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2009, vol. 18, nr 4, July-August, p. 381–384

Publication type: original article

Language: English

Use of Glubran 2 Surgical Glue in Circumcision Results in a Comfortable Postoperative Period

Zastosowanie kleju chirurgicznego Glubran 2 w zabiegach obrzezania a okres pooperacyjny

Hayrettin Ozturk1,, Kazim Karaaslan,, Hasan Kocoglu,

1

Abstract

Objectives. The aim of this study was to evaluate the effects of Glubran 2 on bleeding, wound healing, and patient comfort in the postoperative period together with its effectiveness in approximating the skin edges in circumcision. Material and Methods: A total of 247 patients (age range: 1–12 years) underwent circumcision using a suture for wound approximation (group 1, n = 57) or circumcision using Glubran 2 surgical glue after subcuticular skin closure (group 2, n = 190). The circumcision was performed using a sleeve technique. All patients received standard general anesthesia and caudal blockade with levobupivacaine was applied after anesthesia induction. In group 2, after meticulous hemostasis, the incision was cleansed and the skin edges were approximated in a subcuticular manner. A thin layer of Glubran 2 surgical glue was applied and allowed to dry. Antibiotic ointment was then applied to the glans and penis.
Results. There were no significant differences between the two groups regarding wound inflammation, wound infection, bleeding, wound dehiscence, and edema. However, the cosmetic outcomes and parental satisfaction were consistently greater in group 2.
Conclusion. After approximating the edges subcuticularly after skin closure, using Glubran 2 surgical glue is a safe, comfortable, and cosmetically appealing method in circumcision.

Streszczenie

Cel pracy. Ocena skuteczności kleju Glubran 2 zastosowanego podczas zabiegu obrzezania.
Materiał i metody. 247 pacjentów (wiek 1–12 lat) poddano zabiegowi obrzezania, w tym z użyciem szwu do zbliżenia rany (grupa 1, n = 57) i z zastosowaniem kleju chirurgicznego Glubran 2 po zamknięciu skóry szwem podnaskórkowym (grupa 2, n = 190). Zabieg obrzezania był wykonywany techniką sleeve. U wszystkich pacjentów zabieg przeprowadzono w znieczuleniu ogólnym, a po wprowadzeniu do znieczulenia zastosowano blokadę ogonową z użyciem lewobupiwakainy. Po starannym zapewnieniu hemostazy nacięcie było oczyszczone, a brzegi skóry zbliżone szwem podnaskórkowym. Następnie nakładano cienką warstwę kleju Glubran 2 i pozostawiono do wyschnięcia. Na żołądź i prącie nakładano maść z antybiotykiem.
Wyniki. Między obiema grupami nie zaobserwowano istotnych różnic dotyczących zapalenia, zakażenia rany, krwawienia, rozejścia się rany i obrzęku. Rezultat kosmetyczny i zadowolenie rodziców były lepsze w grupie 2.
Wnioski. Zastosowanie kleju Glubran 2 podczas obrzezania po zbliżeniu brzegów skóry szwem podnaskórkowym jest bezpieczne, wygodne i daje dobre rezultaty kosmetyczne.

Key words

circumcision, tissue glue

Słowa kluczowe

obrzezanie, klej tkankowy

References (12)

  1. Ozkan KU, Gonen M, Sahinkanat T, Resim S, Celik M: Wound approximation with tissue glue in circumcision. Int J Urol 2005, 12, 374–377.
  2. Kavakli K, Nişli G, Özcan C, Avanoglu A, Ulman I, Polat A: Safer and much cheaper circumcision using fibrin glue in severe hemophilia. Haemophilia 1997, 3, 209–211.
  3. Avanoglu A, Celik A, Ulman I, Ozcan C, Kavakli K, Nişli G, Gökdemir A: Safer circumcision in patients with haemophilia: the use of fibrin glue for local haemostasis. BJU Int 1999, 83, 91–94.
  4. Elmore JM, Smith EA, Kirsch AJ: Sutureless circumcision using 2−octyl cyanoacrylate (Dermabond): appraisal after 18−month experience. Urology 2007, 70, 803–806.
  5. Dickneite G, Metzner H, Pfeifer T, Kroez M, Witzke G: A comparison of fibrin sealants in relation to their in vitro and in vivo properties. Thromb Res 2003, 112, 73–82.
  6. Kull S, Martinelli I, Briganti E, Losi P, Spiller D, Tonlorenzi S, Soldani G: Glubran2 Surgical Glue: In vitro Evaluation of Adhesive and Mechanical Properties. J Surg Res 2009 Feb 25 [Epub ahead of print].
  7. Leonardi M, Barbara C, Simonetti L, Giardino R, Aldini NN, Fini M et al.: Glubran 2: A new acrylic glue for neuroradiological endovascular use. Experimental study on animals. Intervent Neuroradiol 2002, 8, 245–250.
  8. Arunachalam P: A prospective comparison of tissue glue versus sutures for circumcision. Pediatr Surg Int 2003, 19, 18–19.
  9. Subramaniam R: Sutureless circumcision: a prospective randomized controlled study. Pediatr Surg Int 2004, 20, 783–785.
  10. Text Atlas of Penile Surgery, Daniel Yachia, Circumcision, p 21–28, Informa UK Ltd, London 2007.
  11. Montanaro L, Arciola CR, Cenni E, Ciapetti G, Savioli F, Filippini F, Barsanti: Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use. Biomaterials 2001, 22, 59–66.
  12. Barillari P, Basso L, Larcinese A, Gozzo P, Indinnimeo M: Cyanoacrylate glue in the treatment of ano−rectal fistulas. Int J Colorectal Dis 2006, 21, 791–794.
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