Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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Advances in Clinical and Experimental Medicine

2008, vol. 17, nr 5, September-October, p. 495–502

Publication type: editorial article

Language: English

The Connection Between Celiac Disease and Nervous System and Mental Disorders

Związek choroby trzewnej z chorobami układu nerwowego i zaburzeniami psychicznymi

Ewa Waszczuk1,, Łukasz Michalski1,, Anna Susło1,, Magdalena Koszewicz2,, Tomasz Adamowski3,, Leszek Paradowski1,

1 Department of Gastroenterology and Hepatology, Silesian Piasts University of Medicine in Wrocław, Poland

2 Department of Neurology, Silesian Piasts University of Medicine in Wrocław, Poland

3 Department of Psychiatry, Silesian Piasts University of Medicine in Wrocław, Poland

Abstract

Celiac disease (CD) is a complex autoimmune enteropathy that affects the small bowel after gluten ingestion in genetically predisposed patients. It is well known that CD may be associated with various neurological manifestations. Celiac disease in adolescents is associated with an increased risk of mental and neurological disorders, especially when there was no diagnosis and treatment of CD in childhood. In most cases these disorders precede the diagnosis of CD and in many cases the symptoms appear to improve after starting a gluten−free diet. Although clinical findings appear to be consistent with a connection between these diseases, the mechanisms involved are unclear and need to be studied further.

Streszczenie

Choroba trzewna jest spowodowana nietolerancją glutenu, który wywołuje autoimmunologiczne reakcje prowadzące do uszkodzenia lub całkowitego zaniku kosmków jelitowych u genetycznie predysponowanych osób. Choroba trzewna może towarzyszyć wielu zaburzeniom neurologicznym. U osób dorosłych wyraźny jest jej związek ze zwiększonym ryzykiem wystąpienia chorób psychicznych oraz zaburzeń neurologicznych, zwłaszcza w przypadku nierozpoznanej i nieleczonej choroby trzewnej w okresie dzieciństwa. W większości przypadków zaburzenia pochodzące z układu nerwowego wyprzedzają rozpoznanie choroby trzewnej, a częstokroć zanikają lub zmniejsza się ich nasilenie po wprowadzeniu diety bezglutenowej. Pomimo że dotychczasowe obserwacje kliniczne potwierdzają związek choroby trzewnej z zaburzeniami pochodzącymi z układu nerwowego, mechanizmy patogenetyczne leżące u podstaw tego zjawiska są wciąż niejasne i wymagają dalszych badań.

Key words

celiac disease, nervous system diseases, mental disorders

Słowa kluczowe

choroba trzewna, choroby układu nerwowego, zaburzenia psychiczne

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