Advances in Clinical and Experimental Medicine
2008, vol. 17, nr 1, January-February, p. 41–33
Publication type: original article
Language: English
Serum Concentrations of Dehydroepiandrosterone Sulfate and Testosterone in Patients with Allergic Rhinitis and Mild Asthma
Stężenie siarczanu dehydroepiandrosteronu i testosteronu w surowicy chorych na alergiczny nieżyt nosa i łagodną astmę oskrzelową
1 Chair and Clinical Department of Internal Diseases, Allergology, and Clinical Immunology, Medical University of Silesia, Katowice, Poland
Abstract
Background. An immuno−modulating effect of dehydroepiandrosterone on IgE−mediated allergic processes has been reported.
Objectives. To assess the serum concentrations of dehydroepiandrosterone sulfate (DHEA−S) and testosterone in female patients suffering from persistent allergic rhinitis (PAR) caused by allergy to house dust mites (HDMs) and seasonal allergic rhinitis (SAR) due to pollen allergy with or without asthma symptoms.
Material and Methods. Serum concentrations of DHEA−S and total testosterone were measured in 23 hitherto untreated female patients sensitized to HDM (Dermayophagoides pteronyssinus, Dermatophagoides farinae) with PAR without (13 patients) and with (10 patients) concomitant symptoms of mild asthma, 22 untreated female patients sensitized to grass and rye pollens with SAR without (12 patients) and with (10 patients) concomitant mild asthma, and 20 healthy subjects.
Results. No significant differences in serum concentrations of DHEA−S and total testosterone were found among the five groups.
Conclusion. It seems that circulating concentrations of DHEA−S and total testosterone are not altered in patients suffering from seasonal or persistent allergic rhinitis with or without concomitant symptoms of mild asthma.
Streszczenie
Wprowadzenie. Obserwowano immunomodulujący wpływ dehydroepiandrosteronu na IgE−zależne procesy alergiczne.
Cel pracy. Ocena stężenia siarczanu dehydroepiandrosteronu (DHEA−S) i testosteronu w surowicy chorych na przewlekły alergiczny nieżyt nosa (PAR) i astmę oskrzelową wywołanych uczuleniem na roztocze kurzu domowego (HDM) oraz chorych na sezonowy alergiczny nieżyt nosa (SAR) i astmę oskrzelową wywołanych uczuleniem na pyłki roślin.
Materiał i metody. Oznaczono stężenie siarczanu dehydroepiandrosteronu i całkowitego testosteronu w surowicy dotychczas nieleczonych 23 kobiet uczulonych na HDM (Dermatophagoides pteronyssinus, Dermatophagoides farinae) chorujących na PAR zarówno bez objawów astmy (13 chorych), jak i z towarzyszącymi objawami łagodnej astmy oskrzelowej (10 chorych), 12 kobiet uczulonych na pyłki traw i zbóż chorych na sezonowy alergiczny nieżyt nosa zarówno bez objawów astmy (12 chorych), jak i z towarzyszącymi objawami łagodnej astmy oskrzelowej (10 chorych) oraz u 20 osób zdrowych.
Wyniki. Nie wykazano statystycznie istotnych różnic w stężeniu DHEA−S i całkowitego testosteronu między badanymi grupami.
Wnioski. Wyniki te sugerują, że stężenia DHEA−S i całkowitego testosteronu w krwi obwodowej nie zmieniają się u chorych na sezonowy i przewlekły alergiczny nieżyt nosa zarówno bez objawów astmy, jak i z towarzyszącymi objawami łagodnej astmy oskrzelowej.
Key words
dehydroepiandrosterone, testosterone, house dust mite, pollen allergy, allergic rhinitis, allergic asthma
Słowa kluczowe
dehydroepiandrosteron, testosteron, roztocze kurzu domowego, alergia na pyłki, alergiczny nieżyt nosa, alergiczna astma
References (17)
- Kroboth PD, Salek FS, Pittenger AL, Fabian TJ, Frye RF: DHEA and DHEA−S: a review. J Clin Pharmacol 1999, 39, 327–348.
- Burger HG: Androgen production in women. Fertil Steril 2002, 77, Suppl 4, S3–5.
- Yesilova Z, Ozata M, Kocar IH, Turan M, Pekel A, Sengul A, Ozdemir IC: The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2000, 85, 66–70.
- Dillon JS: Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders. Curr Drug Targets Inflamm Allergy 2005, 4, 377–385.
- Sudo N, Yu XN, Kubo C: Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice. Immunol Letters 2001, 79, 177–179.
- Tabata N, Tagami H, Terui T: Dehydroepiandrosterone may be one of the regulators of cytokine production in atopic dermatitis. Arch Dermatol Res 1997, 289, 410–414.
- Yu CK, Yang BC, Lei HY, Chen YC, Liu YH, Chen CC, Liu CW: Attenuation of house dust mite Dermatophagoides farinae−induced airway allergic responses in mice by dehydroepiandrosterone is correlated with down−regulation of Th2 response. Clin Exp Allergy 1999, 29, 414–422.
- Straub RH, Lehle K, Herfarth H, Weber M, Falk W, Preuner J, Scholmerich J: Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin−6 and tumor necrosis factor. Eur J Endocrinol 2002, 146, 365–374.
- Nogueira JM, Pinto L P, Loureiro V, Prates S, Gaspar A, Almeida MM, Pinto JE: Soluble CD30, dehydroepiandrosterone sulfate and dehydroepiandrosterone in atopic and non atopic children. Allergy Immunol (Paris) 1998, 30, 3–8.
- Dunn PJ, Mahood CB, Speed JF, Jury DR: Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study. N Z Med J 1984, 97, 805–808.
- Mileva ZH, Maleeva A: The serum testosterone level of patients with bronchial asthma treated with corticosteroids and untreated. Vutr Boles 1998, 27, 29–32.
- Kannisto S, Laatikainen A, Taivainen A, Savolainen K, Tukiainen H, Voutilainen R: Serum dehydroepiandrosterone sulfate concentration as an indicator of adrenocortical suppression during inhaled steroid therapy in adult asthmatic patients. Eur J Endocrinol 2004, 150, 687–690.
- Weinstein RE, Lobocki CA, Gravett S, Hum H, Negrich R, Herbst J, Greenberg D, Pieper DR: Decreased adrenal sex steroid levels in the absence of glucocorticoid suppression in postmenopausal asthmatic women. J Allergy Clin Immunol 1996, 97, 1–8.
- Kos−Kudla B, Ostrowska Z, Marek B, Ciesielska−Kopacz N, Kudla M, Kajdaniuk D, Siemidska L, Strzelczyk J: Circadian serum levels of dehydroepiandrosterone sulphate in postmenopausal asthmatic women before and after long−term hormone replacement. Endocr Regul 2001, 35, 217–222.
- Tabata N, Tagami H, Terui T: Dehydroepiandrosterone may be one of the regulators of cytokine production in atopic dermatitis. Arch Dermatol Res 1997, 289, 410–414.
- Ebata T, Itamura R, Aizawa H, Niimura M: Serum sex hormone levels in adult patients with atopic dermatitis. J Dermatol 1996, 23, 603–605.
- Kasperska−Zając A, Brzoza Z, Rogala B: Serum concentration of dehydroepiandrosterone sulfate and testosterone in female patients suffering from severe atopic/dermatitis syndrome (AEDS). J Invest Allergol Clin Immunnol 2007, 17, 160–163.