Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1 (5-Year IF – 2.0)
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2007, vol. 16, nr 3, May-June, p. 425–433

Publication type: review article

Language: Polish

Apoptoza komórek mięśni gładkich naczyń krwionośnych – znaczenie medyczne

Apoptosis of Vascular Smooth Muscle Cells – the Medical Importance

Monika Buchaniewicz1,, Aleksandra Osada2,

1 Department of Medical Biochemistry Silesian Piasts University of Medicine in Wrocław, Poland

2 Department of Basic Medical Sciences Silesian Piasts University of Medicine in Wrocław, Poland

Streszczenie

Wciągu ostatnich kilku lat apoptoza stała się jednym z najintensywniej badanych zagadnień biologii komórki. Wyniki badań sugerują, że programowana śmierć komórki może odgrywać rolę w procesach fizjologicznych związanych z rozwojem układu krążenia, a także w patogenezie chorób tego układu. Do rozwoju zmian patologicznych może przyczyniać się zarówno nasilenie, jak i zahamowanie apoptozy. Celem niniejszej pracy jest przedstawienie najważniejszych zagadnień związanych z apoptozą zachodzącą w komórkach mięśni gładkich naczyń krwionośnych: regulacji apoptozy i jej potencjalnej roli w rozwoju i leczeniu miażdżycy, nadciśnienia, restenozy występującej po uszkodzeniu naczyń i tętniaka aorty.

Abstract

Apoptosis has become one of the most extensively studied topics in cell biology in the last few years. Obtained data suggest that programmed cell death may play a role in development of vasculature and pathophysiology of its diseases. Apoptosis has pathological implications both when increased or decreased. The aim of this article is to review key points regarding the apoptosis of vascular smooth muscle cells: its regulation and possible role in development and therapy of atherosclerosis, hypertension, restenosis after arterial injury and aortic aneurysm.

Słowa kluczowe

apoptoza, komórki mięśni gładkich, miażdżyca, nadciśnienie tętnicze, restenoza, tętniak aorty

Key words

apoptosis, smooth muscle cells, atheroslcerosis, hipertension, restenosis, aortic aneurysm

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