Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2007, vol. 16, nr 3, May-June, p. 347–352

Publication type: editorial article

Language: English

Cyclooxygenase II – A Role in Gastric Cancer Treatment

Rola cyklooksygenazy w leczeniu raka żołądka

Kenji Ogawa1,, Kazuhiko Yoshimatsu1,

1 Department of Surgery, Tokyo Women’s Medical University Medical Center East, Japan

Abstract

Recent studies have demonstrated that increased amount of prostaglandin E2 (PGE2) produced by overexpression of cyclooxygenase−2 (COX−2)/microsomal PGE synthase−1 (mPGES−1) is involved in tumor proliferation. Furthermore, relationships with epidermal growth factor (EGF)/mitogen activated protein (MAP) kinase signal pathway related to cell proliferation and Akt/protein kinase B (PKB) related to resistance of apoptosis are being clarified. Association of COX−2 with gastric cancer has not been established as clearly as in colon cancer. However, increased expression of COX−2 in gastric cancer was confirmed, and in cell culture or animal models, influence of COX−2 on tumor proliferation was indicated. Thus, the usefulness of COX−2 inhibitor in treatment has been demonstrated. However, in precancerous lesions of gastric cancer, COX−2 expression is controversial and the usefulness of COX−2 inhibitor has not been demonstrated. Further studies about COX−2 and gastric cancer including clinical trials are needed, and also more studies should be performed about other PGE2 related enzymes as well as COX−2.

Key words

cyclooxygenase−2 (COX−2), microsomal prostaglandin E synthase−1 (mPGES−1), gastric cancer, chemoprevention, COX−2 inhibitor

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