Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.727
Index Copernicus  – 166.39
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 6, November-December, p. 1047–1053

Publication type: review article

Language: English

The Influence of Obesity, Distribution of Fat Tissue and Leptin on Risk of Developing of Cardiovascular Disease in Women

Znaczenie otyłości, rozmieszczenia tkanki tłuszczowej i leptyny w występowaniu chorób układu sercowo−naczyniowego u kobiet

Andrzej Dubiński1,, Zygmunt Zdrojewicz2,

1 Regional Health Centre, Internal Ward of Regional Hospital, Kamienna Góra, Poland

2 Chair and Department of Endocrinology and Diabetology, Silesian Piasts University of Medicine, Wrocław, Poland


The role of visceral fat and central obesity on metabolic syndrome and cardiovascular disease was well presented in literature. Comparatively, the role of abdominal subcutaneous fat, especially in women regardless of the degree of obesity, is not well known. In this study is shown the influence of the distribution of abdominal fat, obesity, hypertension and age on leptin concentration and the development of cardiovascular diseases. It is also presented, that the main product of abdominal subcutaneous fat−leptin is produced by female organisms and the concentration of leptin is much higher. This research may provide evidence, that hyperleptinemia and risk of developing of atherosclerosis, especially in postmenopausal women, are strictly connected and hyperleptinemia is of great importance. Key word: leptin, obesity, abdominal subcutaneous fat, hypertension.


Wpływ trzewnej tkanki tłuszczowej i związanej z nią otyłości androidalnej na występowanie zespołu metabolicznego i chorób układu sercowo−naczyniowego przedstawiono w wielu opracowaniach naukowych. Mniej wiadomo o roli, jaką pełni podskórna tkanka tłuszczowa, zwłaszcza u kobiet i to niezależnie od stopnia otyłości. W pracy omówiono wpływ rozmieszczenia tkanki tłuszczowej, otyłości, nadciśnienia tętniczego oraz wieku na stężenie leptyny we krwi oraz występowanie chorób układu sercowo−naczyniowego u kobiet. Wskazano, iż podstawowy produkt podskórnej tkanki tłuszczowej – leptyna jest wytwarzany u kobiet w znacznie większych stężeniach. Przedstawione badania mogą świadczyć o istotnej roli hiperleptynemii w wystąpieniu i progresji miażdżycy u kobiet, zwłaszcza w okresie pomenopauzalnym.

Słowa kluczowe

leptyna, otyłość, tkanka tłuszczowa podskórna, nadciśnienie tętnicze

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