Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 1.736
5-Year Impact Factor – 2.135
Index Copernicus  – 168.52
MEiN – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 5, September-October, p. 949–952

Publication type: review article

Language: Polish

Kisspeptyna – hormon dojrzewania?

Kisspeptin – Hormone of Puberty?

Aleksandra Sztuka1,, Zygmunt Zdrojewicz2,

1 Klinika i Katedra Otolaryngologii AM we Wrocławiu

2 Klinika i Katedra Endokrynologii, Diabetologii i Leczenia Izotopami AM we Wrocławiu

Streszczenie

Kisspeptyna jest hormonem zapoczątkowującym proces dojrzewania. Stymuluje oś podwzgórzowo−przysadkowo−gonadalną, pobudzając wydzielanie hormonów płciowych, co ma szczególne znaczenie w okresie pokwitania. Wśród peptydów zwanych kisspeptynami są znane łańcuchy o 145 (prohormon) oraz 54, 13, 14, i 10 aminokwasach. Są kodowane przez geny KiSS−1. Działają w organizmie jako ligandy, łącząc się z receptorami związanymi z białkiem G. Układ GPR−54/kisspeptyna ma szczególnie istotne znaczenie w okresie dojrzewania, gdyż zapewnia prawidłowy przebieg tego procesu, zapoczątkowując pulsacyjne uwalnianie hormonów LH i FSH. Wrodzone nieprawidłowości tego układu prowadzą do izolowanego hipogonadyzmu ze zmniejszoną ilością hormonów płciowych. Kisspeptyna, zwana też metastatyną, pełni istotną rolę w hamowaniu migracji komórek melanoma in vitro.

Abstract

Kisspeptin is a hormone playing a pivotal role in the onset of puberty. It induces hypotalamic−pituitary−gonadal axis, increasing the level of gonadal hormones in blood, what is very important in the process of onset of puberty. There are chains of 145 amino acides (prohormon) and 10, 13, 14, 54 – aminoacides between peptides called kisspeptins. They are products of translation of KiSS−1 genes (the primary is kisspeptin−145). They play their role as ligands by bounding with receptors coupling with G−protein – GPR−54. Untouched signaling GPR−54/kisspeptin play an important role in the term of puberty, controlling its proper course, initiating pulsating secretion of LH and FSH hormones. Congenital disturbances of this system lead to isolated hypogonadotrophic hypogonadism (IHH). Kisspeptin, called metastatin, plays important role in inhibition of melanoma cells migration in vitro.

Słowa kluczowe

kisspeptyna, receptor GPR−54, metastatyna, hipogonadyzm, dojrzewanie

Key words

kisspeptin, GPR−54 receptor, metastatin, hypogonadism, puberty

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