Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 5, September-October, p. 857–869

Publication type: review article

Language: Polish

Proteinazy Enterococcus faecalis i ich rola w patogenności tego drobnoustroju

Proteinases of Enterococcus faecalis and Their Role in Pathogenicity

Magdalena Kawalec1,, Aleksandra Jakubczak1,2,

1 Zakład Mikrobiologii Molekularnej, Zespół Nauk Mikrobiologicznych, Narodowy Instytut Zdrowia Publicznego w Warszawie

2 Instytut Mikrobiologii, Wydział Biologii Uniwersytetu Warszawskiego

Streszczenie

Poszukiwanie czynników zjadliwości patogenów oportunistycznych, do których zalicza się bakterie z rodzaju Enterococcus, może być kluczem do antybiotykoterapii i profilaktyki wywoływanych przez nie zakażeń w przyszłości. Analizując przebieg kolejnych etapów patogenezy bakteryjnej można zauważyć, że enzymy proteolityczne uczestniczą zarówno w kolonizacji, jak i inwazji oraz omijaniu barier immunologicznych gospodarza, doprowadzając w konsekwencji do zaburzenia homeostazy w jego organizmie. Istnieje zatem potrzeba identyfikacji proteinaz bakteryjnych, szczególnie u wirulentnych szczepów bakterii oportunistycznych, które wywołują trudne do leczenia zakażenia szpitalne. W niniejszej pracy szczegółowo omówiono żelatynazę (GelE) i proteinazę serynową (SprE) E. faecalis – dwa zewnątrzkomórkowe enzymy proteolityczne, których rola w patogenezie wydaje się znacząca.

Abstract

The studies on virulence factors of opportunistic pathogens, including enterococci, may play the key role in the search for the future antibiotic therapy and prophylaxis of infections. Analyzing step by step the conduct of the pathogenesis of bacterial infections one can realize that proteases are engaged in colonization, invasion, and eventual tricking of host’s immune system. Consequently, they are responsible for the break of homeostasis in host’s organism. Though, there is a need for identification of bacterial proteases, especially these produced by more virulent strains of opportunistic pathogens responsible for nosocomial infections. This review is to describe in details gelatinase (GelE) and serine proteinase (SprE) of E. faecalis, which are the two extracellular proteolytic activities with important role to play in enterococcal pathogenesis.

Słowa kluczowe

enterokoki, proteinazy bakteryjne, czynniki zjadliwości, patogenność, kolonizacja, zakażenie

Key words

enterococci, bacterial proteases, virulence factors, pathogenicity, colonisation, infection

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