Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 4, July-August, p. 683–688

Publication type: review article

Language: Polish

Eozynofilowe białko kationowe – znaczenie w patofizjologii i diagnostyce

Eosinophilic Cationic Protein – Its Role in Pathophysiology and Diagnostics

Krzysztof Matusiewicz1,, Krystyna Mowszet1,, Barbara Iwańczak1,, Małgorzata Matusiewicz2,

1 II Katedra i Klinika Pediatrii, Gastroenterologii i Żywienia AM we Wrocławiu

2 Katedra i Zakład Biochemii Lekarskiej AM we Wrocławiu

Streszczenie

W pracy autorzy przedstawili najnowsze doniesienia na temat eozynofilowego białka kationowego i jego znaczenia w patofizjologii i diagnostyce chorób przewodu pokarmowego. Eozynofilowe białko kationowe jest istotnym produktem aktywnych eozynofilów. Jego stężenie w surowicy oraz w zmienionych zapalnie tkankach jest podwyższone w alergii, chorobach pasożytniczych, w eozynofilowym zapaleniu różnych odcinków przewodu pokarmowego, w nieswoistych zapaleniach jelit i jest proporcjonalne do ciężkości procesu patofizjologicznego. W związku z tym jego oznaczanie może być wykorzystywane do diagnostyki i oceny nasilenia procesu chorobowego.

Abstract

In the present work the authors describe the current knowledge on eosinophilic cationic protein and its role in pathophysiology and diagnostics of diseases of the alimentary tract. Eosinophilic cationic protein is a basic product of active eosinophiles. Its concentration in the serum and affected tissues is elevated in allergy, eosinophilic inflammation of various segments of alimentary tract, inflammatory bowel disease. The magnitude of this elevation correlates with gravity of pathophysiological process and can be used in the diagnosis and monitoring disease.

Słowa kluczowe

eozynofilowe białko kationowe, alergia, nieswoiste zapalenia jelita, diagnostyka

Key words

eosinophilic cationic protein, allergy, inflammatory bowel disease, diagnostics

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