Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

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Advances in Clinical and Experimental Medicine

2006, vol. 15, nr 4, July-August, p. 677–681

Publication type: review article

Language: Polish

Ftalany – budowa, działanie, znaczenie kliniczne

Phthalates – Structure, Activity, Clinical Meaning

Kinga Belowska−Bień1,, Zygmunt Zdrojewicz2,

1 Klinika Chorób Wewnętrznych, Zawodowych i Nadciśnienia Tętniczego AM we Wrocławiu

2 Klinika Endokrynologii, Diabetologii i Leczenia Izotopami AM we Wrocławiu

Streszczenie

Ftalany są czynnikami toksycznymi wobec procesów rozwoju i rozmnażania u zwierząt. Są powszechnie używane jako plastyfikatory w produkcji materiałów opartych na PCV i środków medycznych: opakowań preparatów krwi, urządzeń do hemodializy, zgłębników nosowo−żołądkowych i innych. Podejrzewa się, że ftalany zakłócają funkcję układu wewnątrzwydzielniczego, szczególnie przez efekt estrogenopodobny. Ekspozycja na ftalany samców szczurów w czasie życia płodowego powoduje zmiany w obrębie jąder analogiczne do zespołu dysgenetycznego u ludzi. Ftalany powodują spadek stężenia insuliny i kortyzonu w surowicy krwi oraz zawartości glikogenu w wątrobie, a także wzrost stężenia glukozy we krwi oraz T3 i T4 w surowicy. Suplementacja witaminy E zapobiega szkodliwym efektom indukowanym przez ftalany u samic szczurów.

Abstract

Phthalates are developmental and reproductive toxicants in animals. They are widely used as plasticizers in the manufacture of PVC−based materials and medical devices: blood bags, hemodialysis tubing, nasogastric feeding tubes, and others. Phthalates are suspected to disrupt the endocrine system, especially through estrogenic effects. Fetal exposure of male rats to some phthalates induces testicular changes similar to testicular dysgenesis syndrome in humans. Phthalates induce decrease in serum insulin, cortisol and liver glycogen and increase in blood glucose, serum T3 and T4. Vitamin E administration prevents phthalate−induced harmful effects in female rats.

Słowa kluczowe

ftalany

Key words

phthalates

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